一名巴西青少年斑秃患者对托法替布产生极佳反应：病例报告及文献综述

Berbert Ferreira Rachel, Ferreira Sineida Berbert, Scheinberg Morton Aaron

Faculdade de Medicina Centro Universitario Cesumar Maringá Brazil.

Private Clinic - Dermatologia Dra. Sineida Berbert Ferreira Maringa Brazil.

Clin Case Rep. 2019 Nov 21;7(12):2539-2542. doi: 10.1002/ccr3.2484. eCollection 2019 Dec.

Alopecia areata is a common autoimmune disease, with a negative impact in health-related quality of life, especially when affecting children and adolescents. Current medical therapies, mainly for severe disease, are not effective. There are no FDA (Food and Drug Administration)- or ANVISA (Agência Nacional de Vigilância Sanitária)-approved therapy for children with alopecia areata. JAK inhibitors are emerging as a promising therapy.

斑秃是一种常见的自身免疫性疾病，对健康相关生活质量有负面影响，尤其是在影响儿童和青少年时。目前的药物治疗主要针对严重疾病，效果不佳。对于斑秃儿童，尚无美国食品药品监督管理局（FDA）或巴西国家卫生监督局（ANVISA）批准的治疗方法。Janus激酶（JAK）抑制剂正成为一种有前景的治疗方法。