Department of Pediatrics and Child Health, Nihon University School of Medicine, Chiyoda, Japan.
Adv Exp Med Biol. 2020;1232:19-24. doi: 10.1007/978-3-030-34461-0_3.
The Consensus on Resuscitation Science and Treatment Recommendations indicate the target SpO2 values during the first 10 min of life. There are a few studies of values of brain regional saturation of oxygen (rSO2) in newborns, conventional instruments are large and not suitable for measuring in the delivery room. The purpose of this study was to develop reference values for brain rSO2 up to 10 min after birth and to review the changes in cerebral oxygenation in late preterm and term newborn infants immediately after birth.
We evaluated both brain rSO2 and SpO2 at 1, 3, 5 and 10 min after birth in 100 neonates. rSO2, was measured at the forehead using a finger-mounted oximeter. This is 1/100 the size of conventional NIRS and can be carried. To measure SpO2, a Radical-7 was used. This study was approved by the institutional review board at our hospital.
The gestational age and birth weight were 37.9 ± 1.2 weeks and 2825 ± 429 g, respectively. Eighty-seven infants and 13 infants were term and late preterm infants, respectively, and there were 21 vaginal deliveries and 79 cesarean sections. In all cases, rSO2 levels were measured at 1, 3, 5, and 10 min after birth. For the SpO2 measurements, nine cases at 1 min, 40 cases at 3 min, 81 cases at 5 min and 93 cases at 10 min were available. The median rSO2 level was 43% at 1 min after birth, 48% at 3 min, 52% at 5 min and 57% at 10 min.
We used a finger-mounted oximeter to observe changes in brain rSO2 values of 100 normal transition infants. It was easier to detect rSO2 in comparison to the peripheral oxygen saturation monitored by our pulse oximeter. Brain rSO2 values might be useful to evaluate oxygenation immediately after birth.
建立脑区域氧饱和度（rSO2）在出生后 10 分钟内的参考值，并研究晚期早产儿和足月儿出生即刻脑氧合的变化。
本研究共纳入 100 例新生儿，在出生后 1、3、5 和 10 分钟时分别评估脑 rSO2 和 SpO2。使用手指式血氧仪在前额测量 rSO2。该仪器的大小为传统近红外光谱仪的 1/100，可以携带。使用 Radical-7 测量 SpO2。本研究经我院机构审查委员会批准。
胎龄和出生体重分别为 37.9±1.2 周和 2825±429g。87 例为足月儿，13 例为晚期早产儿，阴道分娩 21 例，剖宫产 79 例。所有新生儿均在出生后 1、3、5 和 10 分钟时测量 rSO2。对于 SpO2 测量，有 9 例在 1 分钟时，40 例在 3 分钟时，81 例在 5 分钟时，93 例在 10 分钟时进行了测量。出生后 1 分钟时 rSO2 中位数为 43%，3 分钟时为 48%，5 分钟时为 52%，10 分钟时为 57%。
我们使用手指式血氧仪观察了 100 例正常过渡新生儿脑 rSO2 值的变化。与我们的脉搏血氧仪监测的外周血氧饱和度相比，rSO2 更容易检测到。脑 rSO2 值可能有助于评估出生即刻的氧合情况。
