Institute of Complementary and Integrative Medicine, University of Bern, Bern, Switzerland.
Biomedical Optics Research Laboratory, Department of Neonatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Adv Exp Med Biol. 2020;1232:105-112. doi: 10.1007/978-3-030-34461-0_15.
We have repeatedly observed a right-left asymmetry (RLA) of prefrontal cerebral oxygenation of subjects during the resting state.
To clarify if the RLA is a reliably observable phenomenon at the group level and whether it is associated with systemic physiology, absolute tissue oxygen saturation (StO) or total hemoglobin concentration ([tHb]).
StO and [tHb] values at the right and left prefrontal cortex (PFC) were calculated for two 5- min resting phases based on data from 76 single measurements (24 healthy adults, aged 22.0 ± 6.4 years). StO and [tHb] were measured with an ISS OxiplexTS frequency domain near-infrared spectroscopy device. In addition, end-tidal CO (PCO), heart rate (HR), respiration rate (RR) and the pulse-respiration quotient (PRQ = HR/RR) were measured and analyzed for the two phases.
On the group level it was found that i) StO was higher at the right compared to the left PFC (for both phases), ii) RLA of StO (∆StO = StO (right)-StO (left) was independent of PCO, HR and PRQ, and iii) ∆StO was associated with absolute StO and [tHb] values (positively and negatively, respectively).
This study shows that i) RLA of StO at the PFC is a real phenomenon, and that ii) ∆StO at the group level does not depend on PCO, HR, RR or PRQ, but on absolute StO and [tHb]. We conclude that the RLA is a real effect, independent of systemic physiology, and most likely reflects genuine properties of the brain, i.e. different activity states of the two hemispheres.
我们曾多次观察到静息状态下被试前额叶大脑氧合的左右不对称（RLA）。
明确 RLA 是否是群体水平上可重复观察到的现象，以及它是否与全身生理学、绝对组织氧饱和度（StO）或总血红蛋白浓度（[tHb]）有关。
根据 76 次单次测量（24 名健康成年人，年龄 22.0±6.4 岁）的数据，计算右侧和左侧前额叶皮质（PFC）的 StO 和 [tHb]值，各有两个 5 分钟的静息期。使用 ISS OxiplexTS 频域近红外光谱仪测量 StO 和 [tHb]。此外，还测量和分析了两个阶段的呼气末 CO（PCO）、心率（HR）、呼吸频率（RR）和脉搏呼吸比（PRQ=HR/RR）。
在群体水平上发现：i）StO 右侧高于左侧 PFC（两个阶段均如此）；ii）StO 的 RLA（∆StO=StO（右侧）-StO（左侧）与 PCO、HR 和 PRQ 无关；iii）∆StO 与绝对 StO 和 [tHb]值相关（分别为正相关和负相关）。
本研究表明：i）PFC 处 StO 的 RLA 是一种真实现象；ii）群体水平上的 ∆StO 不依赖于 PCO、HR、RR 或 PRQ，而是依赖于绝对 StO 和 [tHb]。我们得出结论，RLA 是一种真实的效应，独立于全身生理学，很可能反映了大脑的真实特性，即两个半球的不同活动状态。
