Institute of Complementary and Integrative Medicine, University of Bern, Bern, Switzerland.
Biomedical Optics Research Laboratory, Department of Neonatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Adv Exp Med Biol. 2024;1463:67-72. doi: 10.1007/978-3-031-67458-7_12.
BACKGROUND: In our previous studies, we investigated the right-left asymmetry (RLA) of cerebral tissue oxygenation (StO) at rest in humans and the influence of the individual chronotype (i.e. individual chronobiological disposition) on StO. The aim of the current study was to investigate (i) whether the RLA exists during a cognitive task and coloured light exposure (CLE), and (ii) how changes in StO induced by CLE and cognitive performance during a 2-back task are related to the subject's chronotype. METHODS: 36 healthy subjects (22 female, 14 male, age 26.3 ± 5.7 years) were studied twice on two different days. They were exposed to a sequence of blue followed by red light or vice versa in a randomised crossover study design. During CLE, subjects were asked to perform a 2-back task. We measured StO of the right and left prefrontal cortex (PFC) as well as the right and left visual cortex with functional near-infrared spectroscopy (fNIRS). At the behavioural level, we recorded the number of correct and incorrect answers given by the subjects. The chronotype was determined with the Horne and Östberg morningness-eveningness questionnaire. RESULTS: (i) We found that the blue and red light caused a RLA in the PFC. For red light exposure, the 2-back performance was negatively correlated with StO in the right PFC (r = -0.283, p = 0.016), and for blue light, exposure in the left PFC (r = -0.326, p = 0.005). (ii) 83% of subjects who performed the 2-back task at their optimal time of day according to their chronotype showed increased and higher changes in StO (ΔStO > 1%) compared to subjects who did not exercise at their optimal time of day. (iii) No correlation was found between chronotype and 2-back task performance (red: p = 0.38; blue: p = 0.42). CONCLUSIONS: We found for the first time that blue and red light exposure target different regions of the PFC during performance of a 2-back task, which can be explained by the approach and withdrawal model. These results illustrate that studying the subregions (i.e. right, left, and even centre) of the cortex provides a better understanding of the CLE effects in the human brain. Our study also shows that individual chronotype plays an important role in the individual changes in StO induced by CLE.
背景：在我们之前的研究中，我们研究了人类在休息时大脑组织氧合（StO）的左右不对称（RLA），以及个体时型（即个体的生物钟特征）对 StO 的影响。本研究的目的是调查：（i）在认知任务和彩色光暴露（CLE）期间是否存在 RLA，以及（ii）CLE 和 2 -back 任务期间的 StO 变化与被试的时型如何相关。
方法：36 名健康受试者（22 名女性，14 名男性，年龄 26.3±5.7 岁）在两天内进行了两次研究。他们在随机交叉研究设计中接受了蓝色和红色光的顺序暴露或相反顺序的暴露。在 CLE 期间，要求受试者执行 2-back 任务。我们使用功能近红外光谱（fNIRS）测量了右前额叶皮质（PFC）和左前额叶皮质以及右和左视觉皮质的 StO。在行为水平上，我们记录了受试者给出的正确和错误答案的数量。时型通过霍恩和奥斯特伯格的晨晚型问卷确定。
结果：（i）我们发现蓝色和红色光引起了 PFC 的 RLA。对于红色光暴露，2-back 表现与右 PFC 的 StO 呈负相关（r=-0.283，p=0.016），而对于蓝色光暴露，与左 PFC 的 StO 呈负相关（r=-0.326，p=0.005）。（ii）根据时型，83%在一天中最佳时间执行 2-back 任务的受试者与未在最佳时间执行 2-back 任务的受试者相比，StO 的变化更大（ΔStO＞1%）。（iii）时型与 2-back 任务表现之间无相关性（红色：p=0.38；蓝色：p=0.42）。
结论：我们首次发现，在执行 2-back 任务期间，蓝色和红色光会靶向 PFC 的不同区域，这可以用接近和回避模型来解释。这些结果表明，研究皮质的亚区（即右、左甚至中心）可以更好地理解 CLE 对人类大脑的影响。我们的研究还表明，个体时型在 CLE 引起的 StO 个体变化中起着重要作用。
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Zotero 插件