Biomedical Optics Research Laboratory (BORL), University of Zurich, Zurich, Switzerland.
Department of Neonatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Adv Exp Med Biol. 2020;1232:285-290. doi: 10.1007/978-3-030-34461-0_36.
In neonatal intensive care units (NICUs), 87.5% of alarms by the monitoring system are false alarms, often caused by the movements of the neonates. Such false alarms are not only stressful for the neonates as well as for their parents and caregivers, but may also lead to longer response times in real critical situations. The aim of this project was to reduce the rates of false alarms by employing machine learning algorithms (MLA), which intelligently analyze data stemming from standard physiological monitoring in combination with cerebral oximetry data (in-house built, OxyPrem).
MATERIALS & METHODS: Four popular MLAs were selected to categorize the alarms as false or real: (i) decision tree (DT), (ii) 5-nearest neighbors (5-NN), (iii) naïve Bayes (NB) and (iv) support vector machine (SVM). We acquired and processed monitoring data (median duration (SD): 54.6 (± 6.9) min) of 14 preterm infants (gestational age: 26 6/7 (± 2 5/7) weeks). A hybrid method of filter and wrapper feature selection generated the candidate subset for training these four MLAs.
A high specificity of >99% was achieved by all four approaches. DT showed the highest sensitivity (87%). The cerebral oximetry data improved the classification accuracy.
DISCUSSION & CONCLUSION: Despite a (as yet) low amount of data for training, the four MLAs achieved an excellent specificity and a promising sensitivity. Presently, the current sensitivity is insufficient since, in the NICU, it is crucial that no real alarms are missed. This will most likely be improved by including more subjects and data in the training of the MLAs, which makes pursuing this approach worthwhile.
采用机器学习算法(MLA),智能分析标准生理监测与脑氧饱和度数据(内部构建,OxyPrem)相结合产生的数据,降低报警误报率。
选择 4 种流行的 MLA 对报警进行分类:(i)决策树(DT),(ii)5 近邻(5-NN),(iii)朴素贝叶斯(NB)和(iv)支持向量机(SVM)。我们获取并处理了 14 名早产儿(胎龄:26 6/7(±2 5/7)周)的监测数据(中位数时长(SD):54.6(±6.9)分钟)。过滤和包装特征选择的混合方法生成了用于训练这 4 个 MLA 的候选子集。
所有 4 种方法的特异性均>99%。DT 的灵敏度最高(87%)。脑氧饱和度数据提高了分类准确性。
尽管训练数据量(目前)较低,但 4 种 MLA 均实现了优异的特异性和有前途的灵敏度。目前,由于在 NICU 中,不能错过任何真实的报警,因此当前的灵敏度还不够。通过在 MLA 的训练中纳入更多的对象和数据,这将很有可能得到改善,因此值得进一步研究。