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带蒂空肠移植小儿食管重建的适应证、手术并发症及长期预后

Indications, Surgical Complications, and Long-Term Outcomes in Pediatric Esophageal Reconstructions with Pedicled Jejunal Interposition Graft.

作者信息

Koivusalo Antti, Suominen Janne, Salminen Jukka, Pakarinen Mikko

机构信息

Department of Pediatric Surgery, Children's Hospital, University of Helsinki, Helsinki, Finland.

Department of Pediatric Cardiac Surgery, Children's Hospital, University of Helsinki, Helsinki, Finland.

出版信息

Eur J Pediatr Surg. 2020 Feb;30(1):111-116. doi: 10.1055/s-0039-3402713. Epub 2020 Jan 1.

Abstract

INTRODUCTION

Several surgical techniques are available for pediatric esophageal reconstruction. We started to use pedicled jejunum interposition graft (PJIG) because other techniques had significant long-term complications. In this retrospective study, the indications, surgical complications, and long-term outcomes were assessed in patients with PJIG.

MATERIALS AND METHODS

With ethical consent, we reviewed the hospital records of 14 patients (7 females) who from 2005 to 2019 underwent a total of 16 esophageal reconstructions with PJIG.

RESULTS

Median age at PJIG was 1.6 (range: 0.2-15) years. Underlying conditions were esophageal atresia (EA) ( = 11) or native esophagus lost by trauma or infection ( = 3). Eight patients with EA underwent PJIG as primary reconstruction and three as a rescue operation after complications in primary repair. Significant surgical complications occurred in 43% of patients. Major reoperations in six (43%) patients included resection and reanastomosis of strictured proximal PJIG ( = 1) and redo PJIG after failure of the first operation ( = 2). Surgical mortality was nil. After a median follow-up of 6.5 (range: 0.7-14) years, 13 (93%) patients survived, and 1 died of congenital heart disease. PJIG failed in three (23%) survivors of whom two underwent graft removal because of life-threatening aspiration and one did not start oral feeds at all. Ten survivors (77%) have full enteral feeds. Respiratory function in the survivors is satisfactory. Two patients have moderate and three mild gastroesophageal reflux symptoms.

CONCLUSION

PJIG was a functional option for a variety of conditions that required esophageal reconstruction. However, significant early and late complications required major surgical revisions.

摘要

引言

小儿食管重建有多种手术技术可供选择。由于其他技术存在严重的长期并发症,我们开始使用带蒂空肠移植术(PJIG)。在这项回顾性研究中,我们评估了接受PJIG手术患者的手术适应症、并发症及长期预后。

材料与方法

经伦理委员会批准,我们回顾性分析了2005年至2019年间14例(7例女性)患者的医院记录,这些患者共接受了16次PJIG食管重建手术。

结果

接受PJIG手术的患者中位年龄为1.6岁(范围:0.2 - 15岁)。基础疾病为食管闭锁(EA)(n = 11)或因外伤或感染导致原食管缺失(n = 3)。8例EA患者接受PJIG作为初次重建手术,3例在初次修复出现并发症后接受PJIG作为挽救手术。43%的患者出现了严重手术并发症。6例(43%)患者进行了再次大手术,包括切除并重新吻合狭窄的近端PJIG(n = 1)以及初次手术失败后再次进行PJIG手术(n = 2)。手术死亡率为零。中位随访6.5年(范围:0.7 - 14年)后,13例(93%)患者存活,1例死于先天性心脏病。3例(23%)存活患者的PJIG手术失败,其中2例因危及生命的误吸而移除移植物,1例根本未开始经口喂养。10例存活患者(77%)能够完全经肠内喂养。存活患者的呼吸功能良好。2例患者有中度胃食管反流症状,3例有轻度症状。

结论

对于各种需要食管重建的疾病,PJIG是一种有效的选择。然而,早期和晚期严重并发症需要进行大型手术修正。

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