Voice production in a MRI-based subject-specific vocal fold model with parametrically controlled medial surface shape.

The goal of this study was to investigate how realistic changes in medial surface shape, as occur in human phonation, affect voice production. In a parametric magnetic resonance imaging-based three-dimensional vocal fold model, the superior and inferior portions of the medial surface were systematically manipulated to produce different medial surface contours similar to those observed in previous excised larynx and in vivo canine larynx experiments. Voice simulations were performed to investigate the differences in the resulting voice production. The results showed that both superior-medial bulging and inferior-medial bulging of the medial surface, which led to an increased vertical thickness and a more rectangular glottal configuration, increased the closed quotient of vocal fold vibration. Changes in medial surface shape also had significant effects on the phonation threshold pressure. The degree of these effects of changes in medial surface shape was larynx specific, and varied significantly depending on the vocal fold cross-sectional geometry and its variation along the anterior-posterior direction. The results suggest that, in addition to vocal fold approximation, surgical interventions of voice disorders should also aim at restoring a rectangular and sufficiently thick medial surface.