Burke J R, Glasgow E F, McCredie D A, Powell H R
Clin Nephrol. 1977 Jan;7(1):38-42.
Three children with cyanotic congenital heart disease who developed transient proteinuria and edema are described. One died of an intercurrent illness but the other two are now well. Renal biopsy findings in all three children demonstrated a mesangial proliferative glomerulonephritis on light microscopy. An unusual ultrastructural appearance of localized electron-dense thickening of the basement membrane of the capillary loops was seen in all three and collagen fibers were present in the mesangium of two. There was slight fusion of foot processes in two specimens and marked fusion in the third. Immunofluorescence in two patients demonstrated IgM staining in both and fibrin in one. The cause of the glomerular lesions is unknown but, among the many possible factors involved, anoxia and increased venous pressure may be important.
本文描述了三名患有青紫型先天性心脏病并出现短暂蛋白尿和水肿的儿童。其中一名儿童死于并发疾病，另外两名儿童目前情况良好。所有三名儿童的肾活检结果在光学显微镜下均显示为系膜增生性肾小球肾炎。在所有三名儿童中均观察到毛细血管袢基底膜局部电子致密增厚的异常超微结构表现，两名儿童的系膜中有胶原纤维。两个标本中足突有轻微融合，第三个标本中足突有明显融合。两名患者的免疫荧光显示两者均有IgM染色，一名患者有纤维蛋白染色。肾小球病变的原因尚不清楚，但在众多可能涉及的因素中，缺氧和静脉压升高可能很重要。
