Hayabuchi Y, Matsuoka S, Akita H, Kuroda Y
Department of Paediatrics, University of Tukoshima School of Medicine, Japan.
Eur J Pediatr. 1993 Nov;152(11):873-6. doi: 10.1007/BF01957519.
This study examines the exacerbating factors of hyperuricaemia in patients with cyanotic congenital heart disease (CCHD). We studied 59 CCHD patients aged 1 month-30 years. The following variables were assessed: serum uric acid levels, red blood cell count, haemoglobin, hematocrit, partial oxygen pressure and arterial oxygen saturation. Uric acid excretion and renal function were also measured in ten patients with serum levels of uric acid greater than 8 mg/dl (hyperuricaemia group). Serum uric acid level correlated significantly with age and severity of polycythaemia. However, it did not correlate with partial oxygen pressure or arterial oxygen saturation. Uric acid excretion was measured in hyperuricaemia group. Urinary uric acid excretion (24 h) was within normal limits in infants but markedly lower in patients over 15 years of age. The aetiology of hyperuricaemia and decreased uric acid fractional excretion and clearance in infants appears to be secondary to diminished excretion of uric acid in concert with uric acid overproduction. Hyperuricaemia in adolescents and adults with CCHD, however, results mainly from age-related impairment of uric acid excretion.
本研究探讨了青紫型先天性心脏病（CCHD）患者高尿酸血症的加重因素。我们研究了59例年龄在1个月至30岁之间的CCHD患者。评估了以下变量：血清尿酸水平、红细胞计数、血红蛋白、血细胞比容、部分氧分压和动脉血氧饱和度。还对10例血清尿酸水平大于8mg/dl的患者（高尿酸血症组）测定了尿酸排泄和肾功能。血清尿酸水平与年龄和红细胞增多症的严重程度显著相关。然而，它与部分氧分压或动脉血氧饱和度无关。对高尿酸血症组进行了尿酸排泄测定。婴儿的尿尿酸排泄（24小时）在正常范围内，但15岁以上患者明显较低。婴儿高尿酸血症以及尿酸排泄分数和清除率降低的病因似乎是尿酸排泄减少与尿酸生成过多共同作用的结果。然而，CCHD青少年和成人的高尿酸血症主要是由与年龄相关的尿酸排泄受损所致。
