Diagnostic & Research Center for Molecular BioMedicine, Medical University of Graz, Neue Stiftingtalstrasse 6, 8010 Graz, Austria.
INSERM, UMRS 1124, 45, Rue des Saints Peres, 750006, Paris, France.
Curr Opin Biotechnol. 2020 Oct;65:45-51. doi: 10.1016/j.copbio.2019.12.004. Epub 2019 Dec 30.
Biological samples such as tissues, blood and other body fluids, plants or seeds, prokaryotic and eukaryotic cells or isolated biomolecules as well as associated data are the essential raw material for research and development in medicine, biotechnology and agriculture. The collection, processing, preservation, and storage of these resources, in addition to provision of access, are key activities of biobanks or biological resource centres. Biobanks have to ensure proper quality of samples and data, ethical and legal compliance as well as transparent and efficient access procedures. In this context the review places special emphasis on pre-analytical procedures and international standards, which are essential to improving analytical data reliability and reproducibility, as well as on the increasing importance of data management. These requirements of biobanks are demonstrated using the example of pathogen-containing and microbiome biobanks, and refer to needs in cancer research and development.
生物样本，如组织、血液和其他体液、植物或种子、原核和真核细胞或分离的生物分子以及相关数据，是医学、生物技术和农业研究与开发的基本原料。生物库或生物资源中心的主要活动包括这些资源的收集、处理、保存和存储，以及提供获取途径。生物库必须确保样本和数据的质量、遵守伦理和法律规定以及透明和高效的获取程序。在这方面，本综述特别强调了分析前程序和国际标准，这些标准对于提高分析数据的可靠性和可重复性至关重要，同时也强调了数据管理的重要性日益增加。这方面的要求以含有病原体和微生物组的生物库为例进行了说明，并涉及癌症研究与开发方面的需求。
