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对抗真菌药物无反应的甲癣：病因及一种新直接技术的治疗方法

Onychomycosis Unresponsive to Antifungals: Etiology and Treatment with a New Direct Technique.

作者信息

Erdogan Fatma Gülru, Yıldırım Dilsun, Çakır Akay Gül Aslıhan

机构信息

Department of Dermatology, Ufuk University Faculty of Medicine, Turkey.

Department of Dermatology, Sırnak State Hospital, Turkey.

出版信息

Indian J Dermatol. 2019 Nov-Dec;64(6):476-481. doi: 10.4103/ijd.IJD_453_18.

DOI:10.4103/ijd.IJD_453_18
PMID:31896847
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6862374/
Abstract

AIMS AND OBJECTIVES

The aim of this study was to identify the fungal agents causing onychomycosis that were unresponsive to antifungal treatment and to treat these cases by placing under-nail cushions with a mild keratolytic to clear the fungus-invaded tissue.

MATERIALS AND METHODS

Fungal agents were identified by the matrix-assisted laser desorption/ionization time of flight (MALDI-TOF) technique.

RESULTS

Nine patients had spp. (7 , 2 ); four had and one had . All patients were free of infection at the end of treatment.

CONCLUSION

As per the results, we may state that onychomycosis that is unresponsive to treatment in immunocompetent patients seems to be mostly associated with molds. Direct application of a mild keratolytic to the fungus-invaded part, e.g., the nail plate and/or nail bed and removal of fungal elements may provide a successful treatment outcome.

摘要

目的与目标

本研究的目的是确定对抗真菌治疗无反应的甲真菌病致病真菌，并通过放置带有温和角质剥脱剂的甲下垫来治疗这些病例，以清除真菌侵袭的组织。

材料与方法

通过基质辅助激光解吸/电离飞行时间（MALDI-TOF）技术鉴定真菌病原体。

结果

9例患者感染了 spp.（7例 ，2例 ）；4例感染了 ，1例感染了 。所有患者在治疗结束时均无感染。

结论

根据结果，我们可以说，免疫功能正常的患者中对抗真菌治疗无反应的甲真菌病似乎主要与霉菌有关。直接将温和的角质剥脱剂应用于真菌侵袭部位，如甲板和/或甲床，并清除真菌成分，可能会取得成功的治疗效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b63f/6862374/fa163316438d/IJD-64-476-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b63f/6862374/a9b4867abdde/IJD-64-476-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b63f/6862374/8aa0cbdf1e7d/IJD-64-476-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b63f/6862374/32aa1cd468cb/IJD-64-476-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b63f/6862374/e844efbca5ff/IJD-64-476-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b63f/6862374/82dac9ff2677/IJD-64-476-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b63f/6862374/aa03baaafa0b/IJD-64-476-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b63f/6862374/e2198960282f/IJD-64-476-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b63f/6862374/a224aca57e9f/IJD-64-476-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b63f/6862374/fa163316438d/IJD-64-476-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b63f/6862374/a9b4867abdde/IJD-64-476-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b63f/6862374/8aa0cbdf1e7d/IJD-64-476-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b63f/6862374/32aa1cd468cb/IJD-64-476-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b63f/6862374/e844efbca5ff/IJD-64-476-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b63f/6862374/82dac9ff2677/IJD-64-476-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b63f/6862374/aa03baaafa0b/IJD-64-476-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b63f/6862374/e2198960282f/IJD-64-476-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b63f/6862374/a224aca57e9f/IJD-64-476-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b63f/6862374/fa163316438d/IJD-64-476-g009.jpg

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