Sun Yang, Zhao Chunlin, Ye Yanwei, Wang Zhen, He Yuanhang, Li Yulin, Mao Haoxun
Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Department of Breast and Thyroid Surgery, Nanyang Central Hospital, Nanyang, Henan 473000, P.R. China.
Oncol Lett. 2020 Jan;19(1):93-102. doi: 10.3892/ol.2019.11088. Epub 2019 Nov 13.
Fibronectin 1 () is involved in the occurrence and development of various tumors and is upregulated in multiple cancer types. has been demonstrated to promote cell proliferation and migration in gastric cancer cell lines. However, the relationship between the expression of and clinicopathological factors and prognosis is not clear in gastric cancer (GC). The aim of the present study was to investigate the association between expression and clinicopathology and prognosis of gastric cancer. In this study, 17 publicly available GC cohorts (n=2,376) with gene expression data from the Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA) and Oncomine databases were tested. In addition, protein expression was validated by immunohistochemistry in a separate cohort (n=190). The meta-analysis results demonstrated an increase in expression at the protein and mRNA level in GC tissues, and the gene was highly expressed at the mRNA level in the advanced T stage (T2 + T3 + T4) group compared with that in the early T stage (T1) group. In addition, the expression of epithelial at the protein level was positively correlated with tumor size. expression at the protein and mRNA level was a predictor of poor prognosis following radical resection of GC. In conclusion, the expression of in GC tissues is upregulated compared with adjacent normal tissues, and it is a potential biomarker of poor prognosis in patients with GC.
纤连蛋白1（）参与多种肿瘤的发生发展，在多种癌症类型中表达上调。已证实在胃癌细胞系中可促进细胞增殖和迁移。然而，在胃癌（GC）中，其表达与临床病理因素及预后之间的关系尚不清楚。本研究的目的是探讨其表达与胃癌临床病理及预后之间的关联。在本研究中，对来自基因表达综合数据库（GEO）、癌症基因组图谱（TCGA）和Oncomine数据库的17个公开可用的GC队列（n = 2376）进行了基因表达数据检测。此外，在另一个队列（n = 190）中通过免疫组织化学验证了蛋白表达。荟萃分析结果表明，GC组织中蛋白和mRNA水平的表达增加，与早期T期（T1）组相比，在晚期T期（T2 + T3 + T4）组中基因在mRNA水平上高表达。此外，上皮蛋白水平的表达与肿瘤大小呈正相关。蛋白和mRNA水平的表达是GC根治性切除术后预后不良的预测指标。总之，与相邻正常组织相比，GC组织中的表达上调，它是GC患者预后不良的潜在生物标志物。
