Taylor C G, Mascarós E, Román J, Paz M, Santos M, Muñoz A, Gobernado M
Chemotherapy. 1977;23 Suppl 1:310-4. doi: 10.1159/000222068.
The effect of calcium salt of fosfomycin in the treatment of 43 neonates suffering from acute gastroenterocolitis produced by enteropathogenic E. coli is evaluated. The minimal inhibitory concentration of these E. coli was, generally, lower than 128 mug/ml. Dosages of 150-200 mg/kg body weight/day were administered orally every 8 h. This treatment lasted for 4 days only. Clinical evolution was favorable in 38 (88%) babies and bacteriological evolution in 30 (70%). In eight cases a different flora to the initial was selected during the treatment with fosfomycin. None of the cases treated showed any toxic alteration attributed to the antibiotic.
评估了磷霉素钙盐治疗43例由致病性大肠杆菌引起的急性胃肠结肠炎新生儿的效果。这些大肠杆菌的最低抑菌浓度一般低于128微克/毫升。每天口服150 - 200毫克/千克体重，每8小时给药一次。该治疗仅持续4天。38例（88%）婴儿的临床病情好转，30例（70%）细菌学情况改善。8例在磷霉素治疗期间出现了与初始不同的菌群。所有接受治疗的病例均未显示出任何归因于该抗生素的毒性改变。
