Lei Yu, Dong Minyue
School of Medicine, Zhejiang University, Hangzhou 310029, China.
Key Laboratory of Reproductive Genetics, Ministry of Education, Department of Reproductive Genetics, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2019 Jun 25;48(4):409-413. doi: 10.3785/j.issn.1008-9292.2019.08.10.
To analyze the impact of maternal age on sex chromosome aneuploidies (SCA).
Pregnant women who had karyotype analysis of amniotic fluid in Women's Hospital, Zhejiang University School of Medicine from January 2014 to July 2018 were recruited. The association of the maternal age with fetal SCAs was analyzed.
The incidence of 45, X in age group >34-<38 was lower than that of ≤ 28 age group (<0.05). For the incidences of total sex chromosome trisomy and 47, XXY in age groups 34-<38 and ≥38 were higher than age groups ≤28 and >28-34 (<0.05 or <0.01). The incidence of 47, XXX in age group ≥ 38 was higher than that in age group>28-34 (<0.05). However, the incidence of 47, XYY had no differences among the four groups (>0.05). After excluding the high risk of sex chromosome abnormalities by non-invasive prenatal testing (NIPT), we found that for 45, X, the incidences of two groups with advanced age were lower than that of ≤ 28 year-old group of age group (<0.05 or <0.01), and incidence in age group >34-<38 was also lower than that in age group >28-34 (<0.05). The other results were consistent with those without excluding the high risk of sex chromosome abnormalities by NIPT.
Advanced age decreases the incidence of 45, X, but increases the risk of sex chromosome trisomy, especially 47, XXX and 47, XXY.
分析孕妇年龄对性染色体非整倍体（SCA）的影响。
招募2014年1月至2018年7月在浙江大学医学院附属妇产科医院进行羊水染色体核型分析的孕妇。分析孕妇年龄与胎儿SCA的相关性。
年龄>34～<38岁组中45,X的发生率低于年龄≤28岁组（<0.05）。年龄34～<38岁组和≥38岁组的性染色体三体和47,XXY的总发生率高于年龄≤28岁组和>28～34岁组（<0.05或<0.01）。年龄≥38岁组中47,XXX的发生率高于>28～34岁组（<0.05）。然而，47,XYY的发生率在四组之间无差异（>0.05）。通过无创产前检测（NIPT）排除性染色体异常高风险后，我们发现对于45,X，两个高龄组的发生率低于年龄≤28岁组（<0.05或<0.01），且年龄>34～<38岁组的发生率也低于>28～34岁组（<0.05）。其他结果与未通过NIPT排除性染色体异常高风险时一致。
高龄降低了45,X的发生率，但增加了性染色体三体的风险，尤其是47,XXX和47,XXY。
