Department of Orthodontics, Tsurumi University School of Dental Medicine, Yokohama, Japan.
Department of Orthodontics and Dentofacial Orthopedics, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Am J Orthod Dentofacial Orthop. 2020 Jan;157(1):59-66. doi: 10.1016/j.ajodo.2019.01.027.
Because mechanical stimulation of the periodontal ligament by low-intensity pulsed ultrasound (LIPUS) has been shown to increase the speed of bone remodeling, this study aimed to examine the effects of LIPUS stimulation on the rate of tooth movement and bone remodeling during lateral tooth movement.
Twelve-week-old Wistar rats were divided into 2 groups. The LIPUS group received experimental tooth movement with LIPUS stimulation, and the tooth movement (TM) group were provided experimental tooth movement without LIPUS. For each group, the upper right first molars were moved buccally with fixed appliances. LIPUS exposure was placed in the region corresponding to the right maxillary first molar. Three days after tooth movement, tartrate-resistant acid phosphatase was examined. Fourteen days after tooth movement, the intermolar width, bone mineral content, and bone volume fraction were analyzed by micro-computed tomography, and newly formed bone was measured histomorphometrically.
The number of TRAP-positive cells in the compressed region was higher in the LIPUS group. The intermolar width was significantly higher in the LIPUS group than in the TM group. The alveolar bone around the maxillary first molar showed no differences in bone mineral content and bone volume fraction between the LIPUS and TM groups. The LIPUS group exhibited a more significant amount of newly formed alveolar bone than the TM group.
The present study provides evidence of the beneficial effects of LIPUS on the lateral tooth movement.
由于牙周韧带的低强度脉冲超声（LIPUS）机械刺激已被证明可以增加骨重塑的速度，因此本研究旨在探讨 LIPUS 刺激对侧方牙齿移动过程中牙齿移动速度和骨重塑的影响。
将 12 周龄 Wistar 大鼠分为 2 组。LIPUS 组接受 LIPUS 刺激的实验性牙齿移动，牙齿移动（TM）组则进行无 LIPUS 的实验性牙齿移动。对于每组，用固定器械将右上第一磨牙向颊侧移动。LIPUS 照射放置在上颌第一磨牙相应的区域。在牙齿移动后 3 天，检查抗酒石酸酸性磷酸酶。在牙齿移动后 14 天，通过微计算机断层扫描分析磨牙间宽度、骨矿物质含量和骨体积分数，并通过组织形态计量学测量新形成的骨。
LIPUS 组压缩区 TRAP 阳性细胞数量较高。LIPUS 组的磨牙间宽度明显高于 TM 组。上颌第一磨牙周围牙槽骨的骨矿物质含量和骨体积分数在 LIPUS 和 TM 组之间没有差异。LIPUS 组的新形成牙槽骨量明显多于 TM 组。
本研究为 LIPUS 对侧方牙齿移动的有益作用提供了证据。
