Division of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA.
Division of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA.
Kidney Int. 2020 Jan;97(1):29-31. doi: 10.1016/j.kint.2019.10.009.
Membranous nephropathy (MN) is either primary or associated with various etiologies, each with unique glomerular antigens. The discovery of the phospholipase A2 receptor (PLA2R) antigen in primary MN revolutionized our understanding of MN and led to major clinical progress. Other recently discovered antigens in MN include the THSD7A antigen and exostosin. Sethi et al. have now identified a new antigen, NELL-1, in primary MN, again decreasing the number of patients whose antigen remains unknown.
膜性肾病（MN）要么是原发性的，要么与各种病因相关，每种病因都有其独特的肾小球抗原。原发性 MN 中磷脂酶 A2 受体（PLA2R）抗原的发现彻底改变了我们对 MN 的认识，并带来了重大的临床进展。MN 中最近发现的其他抗原还包括 THSD7A 抗原和外多核苷酸酶。塞蒂等人现在在原发性 MN 中又发现了一种新的抗原，NELL-1，这再次减少了抗原仍未知的患者数量。
