Zhou Shuai, Meng FuLei, Yue ShuLing, Li Hang, Zhang LiHong, Wang Tao
HeBei Medical University, Graduate School, ShiJiaZhuang, China.
The First Hospital of HeBei Medical University, Department of Nephrology, ShiJiaZhuang, China.
Clin Kidney J. 2022 Dec 7;16(4):756-759. doi: 10.1093/ckj/sfac261. eCollection 2023 Apr.
We reported the detection of neural epidermal growth factor-like 1 (NELL-1) and immunoglobulin G4 (IgG4) on glomerular capillary wall in membrane nephropathy (MN), which led to the discovery of early post-operative recurrence of esophageal squamous cell cancer (ESCC) in a 68-year-old man. Further, NELL-1 was also identified in the cancerous tissue sampled by esophagoscope. Moreover, serum IgG4 percentage seemed to be higher when comparing with both previous reports and another age-matched male with NELL-1-negative MN upon fully recovered ESCC. Therefore, the finding of NELL-1 in a renal biopsy should trigger a detailed workup in search of malignancy, especially with concomitant IgG4 dominance.
我们报告了在膜性肾病（MN）的肾小球毛细血管壁上检测到神经表皮生长因子样1（NELL-1）和免疫球蛋白G4（IgG4），这使得一名68岁男性食管鳞状细胞癌（ESCC）术后早期复发得以发现。此外，在通过食管镜采集的癌组织中也鉴定出了NELL-1。而且，与之前的报告以及另一名年龄匹配、NELL-1阴性MN且ESCC已完全康复的男性相比，该患者血清IgG4百分比似乎更高。因此，在肾活检中发现NELL-1应引发对恶性肿瘤的详细检查，尤其是在伴有IgG4优势的情况下。
