Affiliated Hospital of Jiangsu University-Yixing People's Hospital, Yixing, Jiangsu 214200, China.
Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
Life Sci. 2020 Aug 1;254:117252. doi: 10.1016/j.lfs.2019.117252. Epub 2020 Jan 2.
Circular RNAs (circRNAs) are a class of covalently closed continuous loops of single-stranded RNA molecules, and broadly expressed in the cytoplasm of eukaryotic cells. CircRNAs have attracted considerable research attention in recent years, an attention primarily attributed to their critical roles in the development and progression of diseases, especially in cancers. The circRNA homeodomain-interacting protein kinase 3 (circHIPK3) is a recently identified circRNA, acknowledged to be relevant to human pathology and cancer progression. Here, we summarize the origin and functions of the circHIPK3 and its target molecules in cancer, and thus, providing a broader knowledge to our current understanding of circRNAs. This review will therefore be essential to enriching our knowledge on the roles of circRNAs in cancers by outlining their potential values and application in the diagnosis and treatment of cancer.
环状 RNA（circRNAs）是一类共价闭合的单链 RNA 分子的连续环，广泛存在于真核细胞的细胞质中。近年来，circRNAs 引起了相当多的研究关注，主要归因于它们在疾病，特别是癌症的发生和发展中的关键作用。环状 RNA 同源结构域相互作用蛋白激酶 3（circHIPK3）是最近发现的一种环状 RNA，被认为与人类病理学和癌症进展有关。在这里，我们总结了 circHIPK3 的起源和功能及其在癌症中的靶分子，从而为我们目前对环状 RNA 的理解提供了更广泛的知识。因此，通过概述环状 RNA 在癌症诊断和治疗中的潜在价值和应用，本综述将丰富我们对环状 RNA 在癌症中的作用的认识，从而使其成为必不可少的一环。
