Li Jian, Su Xin, Xu Xiao, Ye Youbao, Wang Cailiu, Liu Ang, Zhao Changchun, Liu Wenxiu, Yang Liwen, Wang Tao, Hao Xiangyong
Department of General Surgery, The First Clinical Medical College of Gansu University of Chinese Medicine, Gansu Provincial Hospital, No. 204 Donggang West Road, Chengguan District, Lanzhou, 730000, China.
Department of General Surgery, Gansu Provincial Hospital, Lanzhou, 730000, China.
Hum Cell. 2025 May 29;38(4):113. doi: 10.1007/s13577-025-01239-2.
Digestive system tumors are the most common tumors worldwide with high mortality rates. Circular homeodomain-interacting protein kinase 3 (circHIPK3) is a highly abundant and stable circular RNA and have garnered significant attention in the field of cancer research. This review systematically explores potential of circHIPK3 as a clinical biomarker, clinical significance in pharmacotherapy, and molecular mechanisms that regulate biological functions such as cell proliferation, survival, migration, invasion, epithelial-mesenchymal transition, metabolism and angiogenesis in digestive system tumors. Moreover, this review further explored the influence of circHIPK3 on key signaling pathways and the potential clinical value as a diagnostic biomarker and therapeutic target. By delving into the biological functions and molecular mechanisms of circHIPK3, this review aims to provide novel research directions and theoretical guidance for the identification of new therapeutic targets and the development of individualized treatment protocols for digestive system tumors.
消化系统肿瘤是全球最常见的肿瘤，死亡率很高。环状同源结构域相互作用蛋白激酶3（circHIPK3）是一种高度丰富且稳定的环状RNA，在癌症研究领域备受关注。本综述系统地探讨了circHIPK3作为临床生物标志物的潜力、在药物治疗中的临床意义，以及调节消化系统肿瘤细胞增殖、存活、迁移、侵袭、上皮-间质转化、代谢和血管生成等生物学功能的分子机制。此外，本综述进一步探讨了circHIPK3对关键信号通路的影响以及作为诊断生物标志物和治疗靶点的潜在临床价值。通过深入研究circHIPK3的生物学功能和分子机制，本综述旨在为消化系统肿瘤新治疗靶点的鉴定和个体化治疗方案的制定提供新的研究方向和理论指导。
