Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
Center of Super-Diamond and Advanced Films (COSDAF), Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon Tong, Hong Kong, China.
Biomaterials. 2020 Feb;232:119684. doi: 10.1016/j.biomaterials.2019.119684. Epub 2019 Dec 13.
Development of near-infrared-II (NIR-II) light responsive nano-agents with high photothermal stability, high photothermal conversion efficiency (PCE), and excellent biocompatibility for photoacoustic (PA) imaging-guided photothermal therapy (PTT) is of tremendous significance. In spite of the superiority of organic semiconducting polymer nanoparticles (OSPNs) in PA imaging-guided PTT, the limited absorption in the first NIR (NIR-I) window and metastable nanostructure of OSPNs resulting from commonly used preparation methods based on nanoprecipitation or reprecipitation compromise their in vivo phototheranostic performance. Herein we design and synthesize a novel NIR-II absorbing organic semiconducting polymer amphiphile (OSPA) to enhance the structural stability of OSPNs. With prominent optical properties, low toxicity, and a suitable size, OSPA not only efficiently labels and kills cancer cells under NIR-II irradiation but also accumulates at the tumor of living mice upon intravenous injection, allowing efficient NIR-II light-triggered phototheranostics toward tumor. The developed OSPA has promising potential for fabricating multifunctional nanoplatforms to enable multimodal theranostics.
开发具有高光热稳定性、高光热转换效率（PCE）和优异生物相容性的近红外-II（NIR-II）光响应纳米制剂，用于声（PA）成像引导光热治疗（PTT），具有重要意义。尽管有机半导体聚合物纳米粒子（OSPNs）在 PA 成像引导 PTT 方面具有优势，但常用的基于纳米沉淀或再沉淀的制备方法所导致的 OSPNs 在第一近红外（NIR-I）窗口中的有限吸收和亚稳态纳米结构，影响了其在体内光疗诊断性能。在此，我们设计并合成了一种新型的 NIR-II 吸收有机半导体聚合物两亲物（OSPA），以增强 OSPNs 的结构稳定性。OSPA 具有突出的光学性质、低毒性和合适的尺寸，不仅能在 NIR-II 照射下有效标记和杀死癌细胞，而且能在静脉注射后在活体小鼠的肿瘤部位聚集，实现对肿瘤的高效 NIR-II 光触发光疗诊断。所开发的 OSPA 具有制备多功能纳米平台的巨大潜力，可实现多模式治疗诊断。
