新型胃肠外给药青霉烯类药物HRE 664的抗菌活性
Antibacterial activity of HRE 664, a new parenteral penem.
作者信息
Cullmann W, Stieglitz M
机构信息
Department of Medical Microbiology and Immunology, Ruhr-University Bochum, Federal Republic of Germany.
出版信息
Antimicrob Agents Chemother. 1988 Jul;32(7):1090-3. doi: 10.1128/AAC.32.7.1090.
The antibacterial activity of the new penem compound HRE 664 was evaluated in 451 clinical isolates, including ampicillin-resistant members of the family Enterobacteriaceae, Acinetobacter spp., Haemophilus influenzae, Staphylococcus aureus, and beta-hemolytic streptococci, and compared with those of piperacillin, ceftazidime, ceftriaxone, aztreonam, imipenem, and the penem compound Sch 34343. The new agent HRE 664 exhibited antibacterial activity comparable to that of the penem Sch 34343 and imipenem. The MICs of the new agent HRE 664 for 90% of the strains tested ranged from 1 to 4 micrograms/ml against Enterobacteriaceae and were 0.06 micrograms/ml for Staphylococcus aureus and 0.125 micrograms/ml for beta-hemolytic streptococci.
新型青霉烯化合物HRE 664的抗菌活性在451株临床分离菌中进行了评估，这些分离菌包括对氨苄西林耐药的肠杆菌科细菌、不动杆菌属、流感嗜血杆菌、金黄色葡萄球菌和β-溶血性链球菌，并与哌拉西林、头孢他啶、头孢曲松、氨曲南、亚胺培南以及青霉烯化合物Sch 34343的抗菌活性进行了比较。新型药物HRE 664的抗菌活性与青霉烯Sch 34343和亚胺培南相当。新型药物HRE 664对90%受试菌株的最低抑菌浓度（MIC），针对肠杆菌科细菌为1至4微克/毫升，对金黄色葡萄球菌为0.06微克/毫升，对β-溶血性链球菌为0.125微克/毫升。
Zotero 插件