HRE 664，一种新型肠胃外给药的青霉烯类药物。I. 体外抗菌活性

HRE 664, a new parenteral penem. I. Antibacterial activity in vitro.

作者信息

Seibert G, Isert D, Klesel N, Limbert M, Pries A, Schrinner E, Cooke M, Walmsley J, Bentley P H

出版信息

J Antibiot (Tokyo). 1987 May;40(5):660-7. doi: 10.7164/antibiotics.40.660.

DOI:10.7164/antibiotics.40.660

Abstract

The new penem antibiotic HRE 664 displays potent antibacterial activity in vitro against a broad spectrum of clinically relevant bacterial strains including Gram-negative and Gram-positive aerobes and anaerobes. With an MIC 90% of 0.43 micrograms/ml, it is also active against methicillin-resistant staphylococci. HRE 664 is extremely stable against beta-lactamases, it binds preferentially to the penicillin-binding proteins 2, 3, 5 and 6 of Escherichia coli.

摘要

新型青霉烯类抗生素HRE 664在体外对多种临床相关细菌菌株具有强大的抗菌活性，包括革兰氏阴性和革兰氏阳性需氧菌及厌氧菌。其90%的最低抑菌浓度（MIC）为0.43微克/毫升，对耐甲氧西林葡萄球菌也有活性。HRE 664对β-内酰胺酶极其稳定，它优先与大肠杆菌的青霉素结合蛋白2、3、5和6结合。