School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, China.
Mikrochim Acta. 2020 Jan 4;187(1):94. doi: 10.1007/s00604-019-4083-4.
Poly(3,4-ethylenedioxythiophene) (PEDOT) films were electrodeposited by cyclic voltammetry on a glassy carbon electrode (GCE) in aqueous solution. Three kinds of supporting electrolytes were used, viz. graphene oxide (GO), phosphate buffered saline (PBS), and GO in PBS, respectively. The surface morphology of the modified electrodes was characterized by scanning electron microscopy. The electrochemical performance of the modified electrodes was investigated by cyclic voltammetry and electrochemical impedance spectroscopy by using the hexacyanoferrate redox system. The results demonstrate that the PEDOT-GO/GCE, which was electropolymerized in aqueous solutions containing EDOT and GO, shows the best electrochemical activities compared with other modified electrodes. The electrochemical behaviors of ascorbic acid (AA), dopamine (DA) and uric acid (UA) were investigated by cyclic voltammetry. The PEDOT-GO/GCE exhibits enhanced electrocatalytic activities towards these important biomolecules. Under physiological pH conditions and in the mixed system of AA, DA and UA, the modified GCE exhibits the following figures of merit: (a) a linear voltammetric response in the concentration ranges of 100-1000 μM for AA, 6.0-200 μM for DA, and 40-240 μM for UA; (b) well separated oxidation peaks near 31, 213 and 342 mV (vs. saturated Ag/AgCl) for AA, DA and UA, respectively; and (c) detection of limits (at S/N = 3) of 20, 2.0 and 10 μM. The results demonstrate that GO, based on its relatively large number of anionic sites, can be used as the sole weak electrolyte and charge balance dopant for the preparation of functionally doped conducting polymers by electrodeposition. Graphical abstractSchematic representation of a nanostructure composed of hybrid conducting polymer PEDOT-GO nanocomposites, and its application to simultaneous determination of ascorbic acid, dopamine and uric acid.
聚（3,4-亚乙基二氧噻吩）（PEDOT）薄膜通过循环伏安法在玻碳电极（GCE）上在水溶液中电沉积。使用了三种支持电解质，即氧化石墨烯（GO）、磷酸盐缓冲盐水（PBS）和 PBS 中的 GO。通过扫描电子显微镜对修饰电极的表面形貌进行了表征。通过循环伏安法和电化学阻抗谱法，使用亚铁氰化铁氧化还原体系研究了修饰电极的电化学性能。结果表明，与其他修饰电极相比，在含有 EDOT 和 GO 的水溶液中电聚合的 PEDOT-GO/GCE 表现出最佳的电化学活性。通过循环伏安法研究了抗坏血酸（AA）、多巴胺（DA）和尿酸（UA）的电化学行为。PEDOT-GO/GCE 对这些重要生物分子表现出增强的电催化活性。在生理 pH 条件下以及在 AA、DA 和 UA 的混合体系中，修饰的 GCE 表现出以下优点：（a）AA 的浓度范围为 100-1000 μM、DA 的浓度范围为 6.0-200 μM、UA 的浓度范围为 40-240 μM 时具有线性伏安响应；（b）AA、DA 和 UA 的氧化峰分别在 31、213 和 342 mV（相对于饱和 Ag/AgCl）附近很好地分离；（c）检测限（S/N = 3）分别为 20、2.0 和 10 μM。结果表明，GO 基于其相对较多的阴离子位点，可以用作唯一的弱电解质和电荷平衡掺杂剂，通过电沉积制备功能掺杂导电聚合物。
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