Shibata Ritsu, Machida Yukino, Hatakeyama Hitoshi, Yoshimura Hisashi, Yamamoto Masami, Ochiai Kazuhiko, Uematsu Kazuyoshi, Michishita Masaki
Department of Veterinary Pathology, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan.
Laboratory of Comparative Cellular Biology, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan.
J Vet Med Sci. 2020 Feb 18;82(2):193-196. doi: 10.1292/jvms.19-0472. Epub 2020 Jan 1.
A 26-year and 6-month-old male sika deer that was kept at the Showa Park, Tokyo, Japan, collapsed and died of severe disease wasting and severe tabefaction. Grossly, numerous masses, 0.3-1.0 cm diameter, were dispersed throughout the liver. The multiple masses were composed of tumor cells, which had hypochromatic nuclei and abundant faintly eosinophilic cytoplasm, arranged in nests of various sizes. Immunohistochemically, tumor cells were positive for cytokeratin, chromogranin A, synaptophysin and gastrin. Ultrastructurally, the cytoplasm of the tumor cells contained abundant membrane-bound electron-dense granules. A metastatic lesion was observed in the renal, hepatic and pancreatic lymph nodes. On the basis of these findings, this tumor was diagnosed as a neuroendocrine carcinoma with metastases to the lymph nodes.
一只26岁6个月大的雄性梅花鹿，饲养于日本东京昭和公园，因严重的疾病消瘦和极度衰弱而倒下死亡。大体检查时，肝脏内散布着许多直径为0.3 - 1.0厘米的肿块。这些多个肿块由肿瘤细胞组成，肿瘤细胞核染色质减少，细胞质丰富且轻度嗜酸性，排列成大小各异的巢状。免疫组织化学检查显示，肿瘤细胞细胞角蛋白、嗜铬粒蛋白A、突触素和胃泌素呈阳性。超微结构检查发现，肿瘤细胞的细胞质中含有丰富的膜结合电子致密颗粒。在肾、肝和胰淋巴结中观察到转移灶。基于这些发现，该肿瘤被诊断为伴有淋巴结转移的神经内分泌癌。
