Zele Diana, Gombač Mitja, Svara Tanja, Vengušt Gorazd
University of Ljubljana, Veterinary Faculty Institute for Breeding and Health Care of Wild Animals, Ljubljana, Slovenia.
Acta Vet Hung. 2011 Sep;59(3):319-25. doi: 10.1556/AVet.2011.018.
A carcinoid tumour in the liver of a red deer hind (Cervus elaphus) is described. Macroscopically, the liver was considerably enlarged with multifocal, firm, yellow and red nodular neoplastic masses, which were histopathologically diagnosed as hepatic carcinoids. The diagnosis was confirmed by modified Grimelius staining, which demonstrated numerous small argyrophilic granules in the cytoplasm of neoplastic cells, and by immunohistochemistry. The neoplastic cells gave a strong positive reaction for neuron-specific enolase (NSE) and synaptophysin and a weak positive reaction for chromogranin A. To our knowledge, this is the first report of a hepatic carcinoid in red deer.
描述了一头马鹿（ Cervus elaphus）母鹿肝脏中的类癌肿瘤。大体上，肝脏显著肿大，有多个坚实的黄色和红色结节状肿瘤性肿块，经组织病理学诊断为肝类癌。通过改良的 Grimelius 染色（显示肿瘤细胞胞质中有大量嗜银小颗粒）和免疫组织化学证实了诊断。肿瘤细胞对神经元特异性烯醇化酶（NSE）和突触素呈强阳性反应，对嗜铬粒蛋白A呈弱阳性反应。据我们所知，这是马鹿肝脏类癌的首例报告。
