硼氢化物中间体为镁催化的对映选择性酮还原反应铺平了道路。
Borohydride intermediates pave the way for magnesium-catalysed enantioselective ketone reduction.
作者信息
Vasilenko Vladislav, Blasius Clemens K, Wadepohl Hubert, Gade Lutz H
机构信息
Anorganisch-Chemisches Institut, Universität Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany.
出版信息
Chem Commun (Camb). 2020 Jan 25;56(8):1203-1206. doi: 10.1039/c9cc09111d. Epub 2020 Jan 6.
A magnesium precatalyst for the highly enantioselective hydro-boration of C[double bond, length as m-dash]O bonds is reported. The mechanistic basis of the unprecedented selectivity of this transformation has been investi-gated experimentally by isolation of catalytic intermediates and theoretically by DFT calculations. The facile formation of a magnesium borohydride species is critical in overcoming competing pathways in the selectivity-determining insertion step.
报道了一种用于C=O键高对映选择性硼氢化反应的镁预催化剂。通过分离催化中间体对这一前所未有的转化选择性的机理基础进行了实验研究，并通过密度泛函理论（DFT）计算进行了理论研究。硼氢化镁物种的容易形成对于在选择性决定插入步骤中克服竞争途径至关重要。
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