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[免疫功能正常患者的隐球菌性脑膜炎——病例报告]

[Cryptococcal meningitis in an immunocompetent patient - a case report].

作者信息

Tóthóvá Melinda, Nováková Dáša, Rogozánová Kristína, Piesecká Ľubica

机构信息

Institute of Microbiology, Faculty Hospital with Policlinic, Nove Zamky, Slovak Republic, e-mail:

出版信息

Klin Mikrobiol Infekc Lek. 2019 Sep;25(3):89-91.

Abstract

Cryptococcal meningitis is a severe neurological infection caused by the yeast Cryptococcus neoformans. It often occurs as an opportunistic infection; rarely, it may be seen in healthy people as well. The most common source of the infection is inhalation of infected bird droppings. The cryptococci may persist in the lungs and nearby lymph nodes for a long time. There are no or mild clinical manifestations of the pulmonary infection. The disease often manifests only after the cryptococci penetrate into the CNS. The case report documents the development of cryptococcal meningitis in an immunocompetent patient. It was diagnosed by microscopic detection of the yeast in the cerebrospinal fluid. The finding was confirmed by detecting cryptococcal DNA in the cerebrospinal fluid and culture. Despite immediate initiation of antifungal therapy and intensive care, the patient died.

摘要

隐球菌性脑膜炎是由新型隐球菌酵母引起的一种严重的神经感染。它常作为机会性感染发生;很少情况下,也可见于健康人。最常见的感染源是吸入受感染的鸟粪。隐球菌可能在肺部和附近淋巴结中长期存在。肺部感染没有或仅有轻微的临床表现。该疾病通常在隐球菌侵入中枢神经系统后才会显现。该病例报告记录了一名免疫功能正常的患者发生隐球菌性脑膜炎的情况。通过在脑脊液中显微镜检测到酵母进行诊断。通过在脑脊液中检测隐球菌DNA和培养证实了这一发现。尽管立即开始了抗真菌治疗和重症监护,患者仍死亡。

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