Department of Child and Adolescent Psychiatry, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands; The Generation R Study Group, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands.
Department of Child and Adolescent Psychiatry, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Pediatrics, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Psychology, Education, and Child Studies, Erasmus School of Social and Behavioral Sciences, Erasmus University Rotterdam, Rotterdam, the Netherlands.
Neuroimage. 2020 Apr 1;209:116514. doi: 10.1016/j.neuroimage.2020.116514. Epub 2020 Jan 2.
Low vitamin D level during pregnancy has been associated with adverse neurodevelopmental outcomes such as autism spectrum disorders (ASD) in children. However, the underlying neurobiological mechanism remains largely unknown. This study investigated the association between gestational 25-hydroxyvitamin D [25(OH)D] concentration and brain morphology in 2597 children at the age of 10 years in the population-based Generation R Study. We studied both 25(OH)D in maternal venous blood in mid-gestation and in umbilical cord blood at delivery, in relation to brain volumetric measures and surface-based cortical metrics including cortical thickness, surface area, and gyrification using linear regression. We found exposure to higher maternal 25(OH)D concentrations in mid-gestation was associated with a larger cerebellar volume in children (b = 0.02, 95%CI 0.001 to 0.04), however this association did not remain after correction for multiple comparisons. In addition, children exposed to persistently deficient (i.e., <25 nmol/L) 25(OH)D concentration from mid-gestation to delivery showed less cerebral gray matter and white matter volumes, as well as smaller surface area and less gyrification at 10 years than those with persistently sufficient (i.e., ≥50 nmol/L) 25(OH)D concentration. These results suggest temporal relationships between gestational vitamin D concentration and brain morphological development in children.
孕期维生素 D 水平较低与儿童自闭症谱系障碍（ASD）等不良神经发育结局有关。然而，其潜在的神经生物学机制在很大程度上仍不清楚。本研究在基于人群的 Generation R 研究中，调查了 2597 名 10 岁儿童的妊娠期 25-羟维生素 D [25(OH)D]浓度与大脑形态之间的关系。我们研究了妊娠中期母体静脉血和分娩时脐静脉血中的 25(OH)D，与脑容量测量和基于表面的皮质指标（包括皮质厚度、表面积和脑回）相关，使用线性回归。我们发现，妊娠中期暴露于较高的母体 25(OH)D 浓度与儿童较大的小脑体积有关（b=0.02，95%CI 0.001 至 0.04），但在经过多次比较校正后，这种关联不再存在。此外，从中孕期到分娩持续暴露于 25(OH)D 浓度不足（即<25 nmol/L）的儿童在 10 岁时大脑灰质和白质体积较小，表面积较小，脑回较少，而持续暴露于 25(OH)D 浓度充足（即≥50 nmol/L）的儿童则较少。这些结果表明，妊娠期间维生素 D 浓度与儿童大脑形态发育之间存在时间关系。
