[Changes of the chief cells of the proper glands of the stomach after bilateral adrenalectomy and the role of the adrenal hormones in the development of these cells].

In the experiment, performed in 150 white male rats, it has been stated, that after bilateral adrenalectomy differentiation of the chief cells is suppressed, their amount in the proper gland decreases and certain dystrophic processes develop, they involve mitochondria, lysosomes and, mainly, protein-synthesizing apparatus. Decrease in the area of the granular endoplasmic reticulum membranes, in the number of fixed forms of ribosomes, in activity of key oxidoreductases--all they essentially inhibit not only the synthesis phase of pepsinogen, but also its secretion. This results in a sharp drop of proteolytic activity of the gastric juice. Using controls (hydrocortisone--6 mg/kg; DOCA--10 mg/kg), it has been stated that these changes after adrenalectomy are chiefly ensured by deficiency of glucocorticoid hormones.