Matsiuk Ia R
Arkh Anat Gistol Embriol. 1988 Jun;94(6):66-71.
In the experiment, performed in 150 white male rats, it has been stated, that after bilateral adrenalectomy differentiation of the chief cells is suppressed, their amount in the proper gland decreases and certain dystrophic processes develop, they involve mitochondria, lysosomes and, mainly, protein-synthesizing apparatus. Decrease in the area of the granular endoplasmic reticulum membranes, in the number of fixed forms of ribosomes, in activity of key oxidoreductases--all they essentially inhibit not only the synthesis phase of pepsinogen, but also its secretion. This results in a sharp drop of proteolytic activity of the gastric juice. Using controls (hydrocortisone--6 mg/kg; DOCA--10 mg/kg), it has been stated that these changes after adrenalectomy are chiefly ensured by deficiency of glucocorticoid hormones.
在对150只雄性白色大鼠进行的实验中发现，双侧肾上腺切除术后，主细胞的分化受到抑制，其在固有腺体中的数量减少，并出现某些营养不良过程，这些过程涉及线粒体、溶酶体，主要是蛋白质合成装置。颗粒内质网膜面积减小、核糖体固定形式数量减少、关键氧化还原酶活性降低——所有这些不仅从根本上抑制了胃蛋白酶原的合成阶段，也抑制了其分泌。这导致胃液的蛋白水解活性急剧下降。通过使用对照（氢化可的松——6毫克/千克；去氧皮质酮——10毫克/千克），发现肾上腺切除术后的这些变化主要是由糖皮质激素缺乏所致。
