[Morphofunctional changes in the parietal cells of the stomach after adrenalectomy].

As demonstrated experiments performed in 150 white male rats by means of light and electron microscopy, cytochemistry with successive morpho-, cytophotometric and biochemical analysis, after bilateral adrenalectomy, inhibition of proliferative processes of cervical epitheliocytes and their differentiation into parietal cells take place. This results in decreasing amount of the latter, in appearance among them not completely differentiated forms. Dystrophic processes develop, manifesting as a decreasing balance of the secretory membranes and destruction of the mitochondrial apparatus, accompanied with a sharp drop in activity of the main oxidoreductases and ATP-ase. The gastric juice acidity decreases. These changes depend mainly on deficiency of glucocorticoid hormones, but not mineralocorticoids.