Eaton M D, Almquist S J
Infect Immun. 1977 Jan;15(1):322-8. doi: 10.1128/iai.15.1.322-328.1977.
C3H/Bi mice developed autoantibodies after repeated inoculations of isolated membranes from primary tissue cultures of a syngeneic ascites lymphoma in which Newcastle disease virus had grown. This was in addition to the tumor transplantation resistance and cytotoxic antibodies previously demonstrated. The complement-fixing antibodies were completely removed from sera by adsorption with ascites tumor cells but only partially by normal mouse liver powder or C3H/Bi erythrocytes. With continued immunization, antibodies to deoxynucleoprotein and heterophile reagins also appeared. After several months, mice showing these serological reactions died with a wasting disease characterized by loss of lymphoid tissue and scarred, atrophied kidneys. No significant antibody response or autoimmune disease occurred in mice receiving membranes from uninfected syngeneic ascites lymphoma.
C3H/Bi小鼠在反复接种来自同基因腹水淋巴瘤原代组织培养物的分离膜后产生了自身抗体，该同基因腹水淋巴瘤曾培养过新城疫病毒。这是除先前证明的肿瘤移植抗性和细胞毒性抗体之外的情况。补体结合抗体通过与腹水肿瘤细胞吸附可从血清中完全去除，但用正常小鼠肝粉或C3H/Bi红细胞吸附只能部分去除。随着持续免疫，抗脱氧核糖核蛋白抗体和嗜异性反应素也出现了。几个月后，出现这些血清学反应的小鼠死于一种消耗性疾病，其特征为淋巴组织丧失以及肾脏瘢痕化和萎缩。接受未感染的同基因腹水淋巴瘤膜的小鼠未出现明显的抗体反应或自身免疫性疾病。
