Sita Giulia, Hrelia Patrizia, Graziosi Agnese, Morroni Fabiana
Department of Pharmacy and BioTechnology, Alma Mater Studiorum-University of Bologna, via Irnerio 48, 40126 Bologna, Italy.
J Clin Med. 2020 Jan 2;9(1):126. doi: 10.3390/jcm9010126.
Mitochondria are dynamic organelles that undergo constant fission and fusion. Mitochondria dysfunction underlies several human disorders, including Alzheimer's disease (AD). Preservation of mitochondrial dynamics is fundamental for regulating the organelle's functions. Several proteins participate in the regulation of mitochondrial morphology and networks, and among these, Mitofusin 2 (Mfn2) has been extensively studied. This review focuses on the role of Mfn2 in mitochondrial dynamics and in the crosstalk between mitochondria and the endoplasmic reticulum, in particular in AD. Understanding how this protein may be related to AD pathogenesis will provide essential information for the development of therapies for diseases linked to disturbed mitochondrial dynamics, as in AD.
线粒体是动态细胞器，不断进行裂变和融合。线粒体功能障碍是包括阿尔茨海默病（AD）在内的多种人类疾病的基础。维持线粒体动态对于调节细胞器功能至关重要。几种蛋白质参与线粒体形态和网络的调节，其中，线粒体融合蛋白2（Mfn2）已得到广泛研究。本综述重点关注Mfn2在线粒体动态以及线粒体与内质网相互作用中的作用，特别是在AD中的作用。了解这种蛋白质与AD发病机制的关系，将为开发与线粒体动态紊乱相关疾病（如AD）的治疗方法提供重要信息。
