Department of Clinical Sciences and Community Health, Università degli Studi di Milano, via A. Vanzetti, 5, 20133 Milan, Italy.
Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, via F. Gallini, 2, 33080 Aviano, Italy.
Nutrients. 2020 Jan 2;12(1):134. doi: 10.3390/nu12010134.
Conclusive evidence on foods, nutrients, or dietary patterns and the risk of renal cell carcinoma (RCC) is lacking in the literature.
We considered data from an Italian hospital-based case-control study (1992-2004) on 767 incident RCC cases and 1534 controls. dietary patterns were identified by applying principal component factor analysis on 28 nutrients derived from a 78-item food-frequency questionnaire. We estimated the odds ratios (ORs) of RCC and corresponding 95% confidence intervals (CIs) for each quartile category (compared to the lowest one) using conditional multiple logistic regression models providing adjustment for major confounding factors.
We identified four dietary patterns, named "Animal products", "Starch-rich", "Vitamins and fiber", and "Cooking oils and dressings". Higher intakes of the "Starch-rich" pattern were positively associated with RCC risk (OR = 1.38, 95% CI: 1.04-1.82 for the highest quartile, = 0.018). The association was inverse with the "Cooking oils and dressings" pattern (OR = 0.61, 95% CI: 0.47-0.80, < 0.001), whereas no association was found with "Animal products" and "Vitamins and fiber" patterns.
Higher intakes of starch-related foods may increase RCC risk, whereas consumption of olive and seed oils may favorably influence RCC risk.
目前文献中缺乏关于食物、营养素或饮食模式与肾细胞癌（RCC）风险的明确证据。
我们考虑了一项意大利基于医院的病例对照研究（1992-2004 年）的数据，该研究共纳入了 767 例新发病例和 1534 例对照。通过对 78 项食物频率问卷中得出的 28 种营养素进行主成分因子分析，确定了饮食模式。我们使用条件多变量逻辑回归模型，调整了主要混杂因素后，估计了每种四分位数（与最低分位数相比）的 RCC 比值比（OR）及其 95%置信区间（CI）。
我们确定了四种饮食模式，分别命名为“动物产品”、“富含淀粉”、“维生素和纤维”和“烹饪油和调味料”。“富含淀粉”模式的摄入量越高，与 RCC 风险呈正相关（最高四分位数的 OR = 1.38，95%CI：1.04-1.82， = 0.018）。与“烹饪油和调味料”模式呈负相关（OR = 0.61，95%CI：0.47-0.80， < 0.001），而与“动物产品”和“维生素和纤维”模式无关联。
较高的淀粉类食物摄入可能会增加 RCC 的风险，而橄榄油和籽油的摄入可能会对 RCC 的风险产生有利影响。
