Facoltà di Medicina e Chirurgia, Istituto di Statistica Medica e Biometria Giulio A. Maccacaro, Università degli Studi di Milano, via Venezian, 1, 20133 Milan, Italy.
Cancer Epidemiol Biomarkers Prev. 2010 Jan;19(1):18-27. doi: 10.1158/1055-9965.EPI-09-0900.
The issue of diet and laryngeal cancer has been rarely addressed considering the potential role of dietary patterns.
We examined this association using data from a case-control study carried out between 1992 and 2000. Cases were 460 histologically confirmed incident laryngeal cancers hospitalized in two Italian areas. Controls were 1,088 subjects hospitalized for acute nonneoplastic diseases unrelated to tobacco or alcohol consumption. Dietary habits were investigated through a 78-item food frequency questionnaire. A posteriori dietary patterns were identified through principal component factor analysis carried out on a selected set of 28 major nutrients. The internal reproducibility, robustness, and reliability of the identified patterns were evaluated. Odds ratios (OR) of laryngeal cancer and 95% confidence intervals (95% CI) were estimated using unconditional multiple logistic regression models on quartiles of factor scores.
We identified five major dietary patterns named "animal products," "starch-rich," "vitamins and fiber," "vegetable unsaturated fatty acids," and "animal unsaturated fatty acids." The vitamins and fiber dietary pattern was inversely associated with laryngeal cancer (OR, 0.35; 95% CI, 0.24-0.52 for the highest versus the lowest score quartile), whereas the animal products (OR, 2.34; 95% CI, 1.59-3.45) and the animal unsaturated fatty acids (OR, 2.07; 95% CI, 1.42-3.01) patterns were directly associated with it. There was no significant association between the vegetable unsaturated fatty acids and the starch-rich patterns and laryngeal cancer risk.
These findings suggest that diets rich in animal products and animal fats are directly related, and those rich in fruit and vegetables inversely related, to laryngeal cancer risk.
考虑到饮食模式的潜在作用，饮食与喉癌之间的关系问题很少受到关注。
我们使用 1992 年至 2000 年间进行的一项病例对照研究的数据来研究这种关联。病例为在意大利两个地区住院的 460 例经组织学证实的喉癌新发病例。对照组为因与烟草或酒精无关的急性非肿瘤疾病住院的 1088 名患者。通过一份包含 78 个食物频率问题的调查问卷来调查饮食习惯。通过对一组 28 种主要营养素进行主成分因子分析，确定潜在的饮食模式。评估了确定模式的内部重现性、稳健性和可靠性。使用非条件多变量逻辑回归模型，根据因子得分的四分位数估计喉癌的比值比（OR）和 95%置信区间（95%CI）。
我们确定了五种主要的饮食模式，分别命名为“动物产品”、“富含淀粉”、“维生素和纤维”、“蔬菜不饱和脂肪酸”和“动物不饱和脂肪酸”。维生素和纤维的饮食模式与喉癌呈负相关（最高与最低四分位得分的比值比，0.35；95%CI，0.24-0.52），而动物产品（比值比，2.34；95%CI，1.59-3.45）和动物不饱和脂肪酸（比值比，2.07；95%CI，1.42-3.01）与喉癌呈正相关。蔬菜不饱和脂肪酸和富含淀粉的饮食模式与喉癌风险之间没有显著关联。
这些发现表明，富含动物产品和动物脂肪的饮食与喉癌风险直接相关，而富含水果和蔬菜的饮食则与喉癌风险呈负相关。
