Ono Y, Iwasaki T, Sekiguchi M, Onodera T
Research Institute, Daiichi Seiyaku Co., Ltd., Tokyo, Japan.
Arzneimittelforschung. 1988 Jul;38(7A):1024-7.
The subacute toxicity of N2-[(N-acetylmuramoyl)-L-alanyl-D-isoglutaminyl]-N6-stearoyl-L-lysine (MDP-Lys (L18), muroctasin), a synthetic muramyl dipeptide, was investigated in mice and dogs. Both species exhibited leukocytosis, immunologically activated appearances of the axillary lymphnode and splenic white pulp, and irritatic lesions at the injection site, when treated with MDP-Lys(L18) for 4 weeks. Anemia, and synovitis were also found in dogs. These findings reflected main pharmacological action of MDP-Lys(L18), though there was some species difference.
研究了合成的胞壁酰二肽N2-[(N-乙酰基胞壁酰)-L-丙氨酰-D-异谷氨酰胺基]-N6-硬脂酰-L-赖氨酸（MDP-Lys(L18)，胞壁酰三肽）对小鼠和犬的亚急性毒性。当用MDP-Lys(L18)处理4周时，两种动物均出现白细胞增多、腋窝淋巴结和脾白髓的免疫激活表现以及注射部位的刺激性病变。犬还出现贫血和滑膜炎。尽管存在一些种属差异，但这些发现反映了MDP-Lys(L18)的主要药理作用。
