鼠李糖脂在小鼠巨噬细胞上的特异性结合位点。
Specific binding sites of muroctasin on murine macrophages.
作者信息
Akasaki M, Masayasu H, Tsukada W, Takegoshi T
机构信息
Research Institute, Daiichi Seiyaku Co., Ltd., Tokyo, Japan.
出版信息
Arzneimittelforschung. 1988 Jul;38(7A):978-80.
PMID:3190804
Abstract
The specific binding sites for N2-[N-acetylmuramoyl)-L-alanyl-D-isoglutaminyl]-N6-stearoyl-L-lysine (MDP-Lys(L18), muroctasin), a synthetic muramyl dipeptide analog, on murine macrophages were investigated using [3H]-MDP-Lys(L18). The specific binding sites were found to be located on macrophage membrane and not to cross-react with MDP. It was also found that MDP-Lys(L18) was not metabolized by macrophages.
摘要
利用[3H]-N2-[N-乙酰胞壁酰)-L-丙氨酰-D-异谷氨酰胺基]-N6-硬脂酰-L-赖氨酸（MDP-Lys(L18)，胞壁酰三肽），一种合成的胞壁酰二肽类似物，研究了其在小鼠巨噬细胞上的特异性结合位点。发现特异性结合位点位于巨噬细胞膜上，且不与MDP发生交叉反应。还发现MDP-Lys(L18)不会被巨噬细胞代谢。
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