谷胱甘肽S-转移酶基因多态性与噪声性听力损失的关联：谷胱甘肽S-转移酶基因多态性与噪声性听力损失
Association of GST gene polymorphism and noise-induced hearing loss: GST gene polymorphism and NIHL.
作者信息
Loukzadeh Ziba, Sani Hadi Eshaghi, Sheikhha Mohammad Hasan, Ratki Farzaneh Morteza
机构信息
Associate professor, Industrial Diseases Research Center, Center of Excellence for Occupational Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Assistant professor, Department of Occupational Medicine, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
出版信息
AIMS Public Health. 2019 Dec 11;6(4):546-553. doi: 10.3934/publichealth.2019.4.546. eCollection 2019.
BACKGROUND
It has been proposed that Noise-induced hearing loss is a complex disease that is combination of environmental and genetic factors. There are inconsistent results concerning the association between variation in glutathione S-transferase () genetic polymorphisms ( rs1049055 and rs10712361) and susceptibility to Noise-induced hearing loss.
OBJECTIVE
This study was designed to assess the association between gene polymorphism and Noise-induced hearing loss among noise-exposed workers. In a case-control study, male workers from tile and ceramic factories were selected randomly. Subjects were classified into two groups according to the result of audiometry: 73 subjects showed Noise-induced hearing loss which was considered in the case group and 87 subjects without hearing loss was enrolled in the control group. The and polymorphism of both groups were assessed by multiplex polymerase chain reaction.
RESULTS
Null and genotypes were more frequent in case group but no significant statistical difference was seen in case and control groups. No significant link between and genotypes was found.
CONCLUSION
This study suggests that the genetic variability of and has no effect on susceptibility to noise induced hearing loss.
背景
有人提出，噪声性听力损失是一种由环境和遗传因素共同导致的复杂疾病。关于谷胱甘肽S-转移酶（）基因多态性（rs1049055和rs10712361）的变异与噪声性听力损失易感性之间的关联，研究结果并不一致。
目的
本研究旨在评估噪声暴露工人中基因多态性与噪声性听力损失之间的关联。在一项病例对照研究中，随机选取了瓷砖和陶瓷厂的男性工人。根据听力测试结果将受试者分为两组：73名受试者出现噪声性听力损失，被纳入病例组；87名未出现听力损失的受试者被纳入对照组。通过多重聚合酶链反应评估两组的和多态性。
结果
病例组中无效和基因型更为常见，但病例组和对照组之间未观察到显著的统计学差异。未发现与基因型之间存在显著关联。
结论
本研究表明，和的基因变异性对噪声性听力损失的易感性没有影响。
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