GSTM1 基因多态性与中国人群噪声性听力损失易感性相关。
Genetic variation in GSTM1 is associated with susceptibility to noise-induced hearing loss in a Chinese population.
机构信息
Department of Occupational Medicine and Environmental Health, the Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China.
出版信息
J Occup Environ Med. 2012 Sep;54(9):1157-62. doi: 10.1097/JOM.0b013e31825902ce.
OBJECTIVES
To investigate whether glutathione S-transferases (GST) genetic polymorphisms (GSTT1 rs1049055, GSTM1 rs10712361, and GSTP1 rs1695) are associated with susceptibility to noise-induced hearing loss (NIHL).
METHODS
These polymorphisms were analyzed in 444 NIHL and 445 normal hearing workers. In addition, total plasma GST activity was measured in all subjects.
RESULTS
Individuals with the GSTM1 null genotype had a statistically significantly increased risk of NIHL (odds ratio [OR] = 1.64, 95% confidence interval [CI] = 1.26 to 2.13) compared with those carrying a wild-type GSTM1 genotype. This effect was more pronounced among the workers exposed to 86 to 91 dB(A) (OR = 3.35, 95% CI = 1.54 to 7.31). Glutathione S-transferase activity of the NIHL workers was also lower than that of normal hearing workers (14.5 ± 5.1 U/ml vs 15.9 ± 6.3 U/ml, P = 0.010).
CONCLUSION
Our results suggest that GSTM1 polymorphism is associated with susceptibility to NIHL.
目的
探讨谷胱甘肽 S-转移酶（GST）基因多态性（GSTT1 rs1049055、GSTM1 rs10712361 和 GSTP1 rs1695）是否与噪声性听力损失（NIHL）易感性相关。
方法
分析了 444 例 NIHL 患者和 445 例听力正常的工人的这些多态性。此外，所有受试者的总血浆 GST 活性均进行了测量。
结果
与携带野生型 GSTM1 基因型的个体相比，GSTM1 缺失基因型个体发生 NIHL 的风险具有统计学显著增加（比值比 [OR] = 1.64，95%置信区间 [CI] = 1.26 至 2.13）。在暴露于 86 至 91 dB(A)的工人中，这种影响更为明显（OR = 3.35，95%CI = 1.54 至 7.31）。NIHL 工人的谷胱甘肽 S-转移酶活性也低于听力正常的工人（14.5 ± 5.1 U/ml 比 15.9 ± 6.3 U/ml，P = 0.010）。
结论
我们的结果表明，GSTM1 多态性与 NIHL 的易感性相关。
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