Knutsson Anki, Björkbacka Harry, Dunér Pontus, Engström Gunnar, Binder Christoph J, Nilsson Anna Hultgårdh, Nilsson Jan
Department of Experimental Medical Science, Lund University, Lund, Sweden.
Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.
JACC Basic Transl Sci. 2019 Nov 6;4(8):891-902. doi: 10.1016/j.jacbts.2019.07.002. eCollection 2019 Dec.
Experimental studies have suggested an atheroprotective role of interleukin (IL)-5 through the stimulation of natural immunoglobulin M antibody expression. In the present study we show that there are no associations between baseline levels of IL-5 and risk for development of coronary events or stroke during a 15.7 ± 6.3 years follow-up of 696 subjects randomly sampled from the Malmö Diet and Cancer study. However, presence of a plaque at the carotid bifurcation was associated with lower IL-5 and IL-5 deficiency resulted in increased plaque development at sites of oscillatory blood flow in mice suggesting a protective role for IL-5 in plaque development.
实验研究表明，白细胞介素（IL）-5 通过刺激天然免疫球蛋白 M 抗体表达发挥抗动脉粥样硬化作用。在本研究中，我们发现，在从马尔默饮食与癌症研究中随机抽取的 696 名受试者长达 15.7±6.3 年的随访中，IL-5 的基线水平与冠状动脉事件或中风发生风险之间无关联。然而，颈动脉分叉处有斑块与较低的 IL-5 相关，且 IL-5 缺乏导致小鼠振荡血流部位的斑块发展增加，提示 IL-5 在斑块发展中起保护作用。
