Budak Emine, Solakoglu Kahraman Dudu, Budak Adnan, Yanarateş Ahmet, Inan Abdurrahman Hamdi, Kanmaz Ahkam Göksel, Beyan Emrah
University of Health Sciences, Izmir Dr. Suat Seren Chest Diseases and Surgery Training and Research Hospital, Department of Nuclear Medicine, Turkey.
Tepecik Training and Research Hospital, Department of Pathology, Izmir, Turkey.
Ginekol Pol. 2019;90(12):675-683. doi: 10.5603/GP.2019.0116.
The present study evaluates the relationship between the expression levels of hormone receptors (HRs), Ki-67, p53 and serum cancer antigen 125 (CA125) levels in endometrial cancer and clinicopathological risk factors, and determines their prognostic values.
This retrospective study included 49 patients with endometrial cancer whose estrogen receptor (ER) and progesterone receptor (PR) Ki-67 and p53 expression levels were determined through immunohistochemical methods, and whose preoperative serum CA125 levels were measured. These factors relationship with various clinicopathological factors, progression-free survival (PFS) and overall survival (OS) was investigated.
The study included 49 patients with EC with a mean age of 61 ± 10 years. The rate of HR positivity was significantly higher in the endometrioid histology group than in the non-endometroid histology group (p = 0.026). A high level of Ki- 67 expression was found to be associated with a non-endometroid histology (p = 0.016), and a high tumor grade (p < 0.001) and a high p53 expression were found to be associated with advanced disease stage (p = 0.026). A positive correlation was found between p53 and Ki-67, a negative correlation was found between p53 and Ki-67 and the presence of HR. Significant relationship was not found between HR status, p53, Ki-67, CA125 and either other clinicopathological risk factors or survival.
While HR positivity indicates favorable clinicopathological prognostic factors, high Ki-67 and high p53 expression indicate unfavorable ones. However, no direct effect of these factors on prognosis was found in this study.
本研究评估子宫内膜癌中激素受体（HRs）、Ki-67、p53的表达水平与血清癌抗原125（CA125）水平之间的关系及其与临床病理危险因素的关联，并确定它们的预后价值。
这项回顾性研究纳入了49例子宫内膜癌患者，通过免疫组化方法测定其雌激素受体（ER）、孕激素受体（PR）、Ki-67和p53的表达水平，并测量其术前血清CA125水平。研究这些因素与各种临床病理因素、无进展生存期（PFS）和总生存期（OS）的关系。
该研究纳入了49例子宫内膜癌患者，平均年龄为61±10岁。子宫内膜样组织学组的HR阳性率显著高于非子宫内膜样组织学组（p = 0.026）。发现Ki-67高表达与非子宫内膜样组织学（p = 0.016）、高肿瘤分级（p < 0.001）相关，p53高表达与疾病晚期（p = 0.026）相关。p53与Ki-67之间呈正相关，p53与Ki-67及HR的存在之间呈负相关。未发现HR状态、p53、Ki-67、CA125与其他临床病理危险因素或生存期之间存在显著关系。
虽然HR阳性表明临床病理预后因素良好，但Ki-67高表达和p53高表达表明预后不良。然而，本研究未发现这些因素对预后有直接影响。
