Flynn R J, McMurray T J, Dwyer R, Moore J
Department of Anaesthetics, Queen's University of Belfast.
Br J Anaesth. 1988 Oct;61(4):382-4. doi: 10.1093/bja/61.4.382.
Twenty patients who requested extradural analgesia for labour were allocated randomly to receive an infusion of either 0.25% or 0.08% solutions of bupivacaine. Following an initial bolus dose of 50 mg, the infusions were given at a rate of 20 mg h-1. Both solutions provided acceptable pain relief, but plasma concentrations were significantly lower with the weaker concentration.
20名要求硬膜外分娩镇痛的患者被随机分配接受0.25%或0.08%布比卡因溶液的输注。在给予50mg初始推注剂量后，以20mg/h的速率进行输注。两种溶液均提供了可接受的疼痛缓解效果，但浓度较低的溶液其血浆浓度显著更低。
