Alston R P
University Department of Anaesthesia, Glasgow Royal Infirmary.
Br J Anaesth. 1988 Oct;61(4):385-9. doi: 10.1093/bja/61.4.385.
In a double-blind study, 0.5% bupivacaine 3 ml in plain (n = 10) or hyperbaric (n = 10) solution was injected intrathecally to 20 patients who were in the sitting position, to produce spinal anaesthesia for transurethral resection of prostate. No statistically significant differences were found in time to maximum cephalad spread of analgesia nor in the level reached. However, the plain solution produced a smaller scatter around the mean level than the hyperbaric solution. The duration of analgesia was not significantly different between two groups. There was no difference in the incidence of complete motor block, but a longer duration of lesser degrees of motor block was found with the plain solution (P less than 0.05). The plain solution produced a more predictable level of blockade.
在一项双盲研究中，将3毫升0.5%的布比卡因普通溶液（n = 10）或重比重溶液（n = 10）经鞘内注射给20例处于坐位的患者，用于经尿道前列腺切除术的脊髓麻醉。在达到最大头向镇痛扩散的时间以及所达到的平面方面，未发现统计学上的显著差异。然而，普通溶液在平均平面周围产生的离散度比重比重溶液小。两组之间的镇痛持续时间无显著差异。完全运动阻滞的发生率没有差异，但普通溶液导致较轻程度运动阻滞的持续时间更长（P小于0.05）。普通溶液产生的阻滞平面更可预测。
