Linearity of metoclopramide kinetics at doses of 5-20 mg.
作者信息
Wright M R, Axelson J E, Rurak D W, McErlane B, McMorland G H, Ongley R C, Tam Y K, Price J D
机构信息
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.
出版信息
Br J Clin Pharmacol. 1988 Oct;26(4):469-73. doi: 10.1111/j.1365-2125.1988.tb03407.x.
Abstract
The disposition of metoclopramide was studied on a four-way crossover basis in six healthy non-smoking volunteers. The linearity of kinetic parameters and absolute bioavailability of metoclopramide were examined. In contrast to previous reports, metoclopramide obeyed linear kinetics over oral doses ranging from 5 to 20 mg. The absolute bioavailability of metoclopramide was 0.76 +/- 0.38 (mean +/- s.d.) from the oral dosage forms examined in this study.
摘要
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