5 - 20毫克剂量下胃复安动力学的线性关系。
Linearity of metoclopramide kinetics at doses of 5-20 mg.
作者信息
Wright M R, Axelson J E, Rurak D W, McErlane B, McMorland G H, Ongley R C, Tam Y K, Price J D
机构信息
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.
出版信息
Br J Clin Pharmacol. 1988 Oct;26(4):469-73. doi: 10.1111/j.1365-2125.1988.tb03407.x.
Abstract
The disposition of metoclopramide was studied on a four-way crossover basis in six healthy non-smoking volunteers. The linearity of kinetic parameters and absolute bioavailability of metoclopramide were examined. In contrast to previous reports, metoclopramide obeyed linear kinetics over oral doses ranging from 5 to 20 mg. The absolute bioavailability of metoclopramide was 0.76 +/- 0.38 (mean +/- s.d.) from the oral dosage forms examined in this study.
摘要
在6名健康不吸烟志愿者中，基于四交叉试验设计研究了甲氧氯普胺的处置情况。研究了甲氧氯普胺动力学参数的线性关系及绝对生物利用度。与既往报道不同，甲氧氯普胺在5至20mg口服剂量范围内遵循线性动力学。本研究中所检测口服剂型的甲氧氯普胺绝对生物利用度为0.76±0.38（均值±标准差）。
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2
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Psychol Med. 1981 May;11(2):257-63. doi: 10.1017/s0033291700052077.
3
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Clin Sci (Lond). 1985 May;68(5):511-5. doi: 10.1042/cs0680511.
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