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载姜黄素和 Bcl-2siRNA 的 PAMAM 树枝状大分子共递药系统增强 HeLa 癌细胞的治疗效果。

Co-delivery of curcumin and Bcl-2 siRNA by PAMAM dendrimers for enhancement of the therapeutic efficacy in HeLa cancer cells.

机构信息

Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.

出版信息

Colloids Surf B Biointerfaces. 2020 Apr;188:110762. doi: 10.1016/j.colsurfb.2019.110762. Epub 2019 Dec 27.

DOI:10.1016/j.colsurfb.2019.110762
PMID:31911391
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7071519/
Abstract

Co-delivery of therapeutic agents and small interfering RNA (siRNA) can be achieved by a suitable nanovehicle. In this work, the solubility and bioavailability of curcumin (Cur) were enhanced by entrapment in a polyamidoamine (PAMAM) dendrimer, and a polyplex was formed by grafting Bcl-2 siRNA onto the surface amine groups to produce PAMAM-Cur/Bcl-2 siRNA nanoparticles (NPs). The synthesized polyplex NPs had a particle size of ∼180 nm, and high Cur loading content of ∼82 wt%. Moreover, the PAMAM-Cur/Bcl-2 siRNA NPs showed more effective cellular uptake, and higher inhibition of tumor cell proliferation compared to PAMAM-Cur nanoformulation and free Cur, due to the combined effect of co-delivery of Cur and Bcl-2 siRNA. The newly described PAMAM-Cur/Bcl-2 siRNA polyplex NPs could be a promising co-delivery nanovehicle.

摘要

通过合适的纳米载体可以实现治疗剂和小干扰 RNA（siRNA）的共递运。在这项工作中，姜黄素（Cur）的溶解度和生物利用度通过包封在聚酰胺-胺（PAMAM）树枝状大分子中得到提高，并通过将 Bcl-2 siRNA 接枝到表面胺基上形成聚阳离子，从而制备出 PAMAM-Cur/Bcl-2 siRNA 纳米粒（NPs）。合成的聚阳离子 NPs 的粒径约为 180nm，Cur 的载药含量高达约 82wt%。此外，与 PAMAM-Cur 纳米制剂和游离 Cur 相比，PAMAM-Cur/Bcl-2 siRNA NPs 具有更高的细胞摄取效率，并且对肿瘤细胞增殖的抑制作用更强，这是由于 Cur 和 Bcl-2 siRNA 的共递运的联合作用。新描述的 PAMAM-Cur/Bcl-2 siRNA 聚阳离子 NPs 可能是一种很有前途的共递运纳米载体。

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Co-delivery of curcumin and Bcl-2 siRNA by PAMAM dendrimers for enhancement of the therapeutic efficacy in HeLa cancer cells.

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本文引用的文献

[1]
Co-delivery of p53 and MDM2 inhibitor RG7388 using a hydroxyl terminal PAMAM dendrimer derivative for synergistic cancer therapy.

Acta Biomater. 2019-9-27

[2]
Curcumin and its Potential for Systemic Targeting of Inflamm-Aging and Metabolic Reprogramming in Cancer.

Int J Mol Sci. 2019-3-8

[3]
Cervical cancer.

Lancet. 2019-1-12

[4]
PAMAM dendrimers as efficient drug and gene delivery nanosystems for cancer therapy.

Appl Mater Today. 2018-9

[5]
Polyester based nanovehicles for siRNA delivery.

Mater Sci Eng C Mater Biol Appl. 2018-5-8

[6]
Cancer hallmarks and malignancy features: Gateway for improved targeted drug delivery.

Biotechnol Adv. 2018-8-2

[7]
Glutathione-responsive self-delivery nanoparticles assembled by curcumin dimer for enhanced intracellular drug delivery.

Int J Pharm. 2018-7-31

[8]
Curcumin-entrapped MUC-1 aptamer targeted dendrimer-gold hybrid nanostructure as a theranostic system for colon adenocarcinoma.

Int J Pharm. 2018-7-23

[9]
Surface functionalized dendrimers as controlled-release delivery nanosystems for tumor targeting.

Eur J Pharm Sci. 2018-7-9

[10]
Poly (amidoamine) (PAMAM) dendrimer mediated delivery of drug and pDNA/siRNA for cancer therapy.

Int J Pharm. 2018-5-19

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