白细胞介素-1α、白细胞介素-1β 和肿瘤坏死因子-α 基因单核苷酸多态性对重度抑郁症发生、严重程度及治疗效果影响的初步研究
Preliminary Study of the Impact of Single-Nucleotide Polymorphisms of IL-1α, IL-1β and TNF-α Genes on the Occurrence, Severity and Treatment Effectiveness of the Major Depressive Disorder.
机构信息
Laboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 141/143 Pomorska Street, 90-236, Lodz, Poland.
Department of Medical Biochemistry, Medical University of Lodz, Lodz, Poland.
出版信息
Cell Mol Neurobiol. 2020 Aug;40(6):1049-1056. doi: 10.1007/s10571-019-00782-5. Epub 2020 Jan 7.
Abstract
The purpose of the preliminary study was to determine whether the occurrence of certain SNPs of genes encoding IL-1α, IL-1β, and TNF-α is associated with the development of depression. Five polymorphisms were selected: i.e. c.-1560G > C-IL-1β (rs1143623), c. -118 C > T-IL-1β (rs1143627), c.340G > T-IL-1α (rs17561), c.-1211T > C-TNF-α (rs1799964) and c.-488G > A-TNF-α (rs1800629). These were analyzed using TaqMan probes. The genotypes of the analyzed polymorphisms were found to be associated with disease severity and may affect the effectiveness of antidepressant therapy. In addition, the gene-gene analysis confirmed that combined genotypes of investigated SNPs may modulate the risk of depression.
摘要
初步研究的目的是确定编码 IL-1α、IL-1β 和 TNF-α 的基因的某些 SNPs 的发生是否与抑郁症的发展有关。选择了五个多态性：即 c.-1560G>C-IL-1β(rs1143623)、c.-118C>T-IL-1β(rs1143627)、c.340G>T-IL-1α(rs17561)、c.-1211T>C-TNF-α(rs1799964)和 c.-488G>A-TNF-α(rs1800629)。这些多态性使用 TaqMan 探针进行分析。分析发现，所分析的多态性的基因型与疾病严重程度相关，并可能影响抗抑郁治疗的效果。此外，基因-基因分析证实，所研究 SNP 的组合基因型可能调节抑郁症的风险。
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