Department of Medical Imaging and Radiation Sciences, Monash University, Victoria, Australia.
Department of Physiology, Monash University, Victoria, Australia.
Anat Rec (Hoboken). 2020 Oct;303(10):2646-2656. doi: 10.1002/ar.24344. Epub 2020 Jan 8.
Obtaining growth and physiologic data in the postnatal laboratory animal is common. However, monitoring growth in utero is far more difficult, with little data available except upon termination of pregnancy. High-resolution ultrasound was used to monitor growth, morphology, and fetal well-being in normotensive and hypertensive rabbits (21 fetuses) at day 16, 20, and 26 of the 32 day gestational period. Set protocols, comparable to those routinely assessed in humans, were devised and followed for each examination. Birth weight was greater in offspring of hypertensive as compared to normotensive mothers (p < 0.001); however, litter size was reduced. The greater birth weight was reflected in growth parameters measured throughout gestation indicating the predictive value of ultrasound. High-resolution ultrasound was a reliable and sensitive method for biometric and morphologic assessment of the fetal rabbit, demonstrating that growth trajectory of offspring of hypertensive mothers may be altered early in gestation.
在产后实验动物中获得生长和生理数据是很常见的。然而，监测宫内生长要困难得多，除了终止妊娠外，几乎没有可用的数据。高分辨率超声用于监测正常血压和高血压兔（21 只胎儿）在妊娠 32 天的第 16、20 和 26 天的生长、形态和胎儿健康状况。为每次检查设计并遵循了与常规评估人类相似的既定方案。与正常血压母亲相比，高血压母亲的后代出生体重更大（p < 0.001）；然而，胎仔数量减少了。在整个妊娠期测量的生长参数反映了更大的出生体重，表明超声具有预测价值。高分辨率超声是一种可靠和敏感的兔胎儿生物计量和形态评估方法，表明高血压母亲后代的生长轨迹可能在妊娠早期发生改变。
