Cantwell Hafsa M, Drage Lisa A, El-Azhary Rokea A, Hall Matthew R, Killian Jill M, Yiannias James A, Davis Mark D P
From the *Department of Dermatology, Mayo Clinic, Rochester, MN †Department of Dermatology, Mayo Clinic, Jacksonville, FL ‡Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN §Department of Dermatology, Mayo Clinic, Scottsdale, AZ.
Dermatitis. 2020 Jan/Feb;31(1):42-52. doi: 10.1097/DER.0000000000000562.
A major question in patch testing is when to perform the final reading. Our current standard practice is to place patches on day 1, remove them on day 3, and perform readings on days 3 and 5. For certain allergens, another reading is performed sometime from days 7 to 14≥.
The aim of the study was to identify allergens with positive reactions on day 5 that were negative on day 7 or later and allergens with negative reactions on day 5 that were subsequently positive on day 7 or later.
We reviewed records of patients who underwent patch testing from January 2007 to December 2016 at Mayo Clinic with readings on day 5 and day 7 or later.
In total, 131 allergens had positive reactions on day 5 that were negative on day 7 or later, and 58 allergens had negative reactions on day 5 that were positive on day 7 or later. Twenty-five allergens had significantly higher reaction rates on day 5 than day 7 or later. Our standard practice is to perform readings on days 3 and 5 and on days 3, 5, and 7 or later for series containing metals. Readings on days 3, 5, and 7 or later should also be considered for acrylates.
斑贴试验中的一个主要问题是何时进行最终读数。我们目前的标准做法是在第1天贴敷斑贴，第3天去除，然后在第3天和第5天进行读数。对于某些变应原，会在第7至14天≥的某个时间进行另一次读数。
本研究的目的是识别在第5天呈阳性反应但在第7天或之后呈阴性反应的变应原，以及在第5天呈阴性反应但随后在第7天或之后呈阳性反应的变应原。
我们回顾了2007年1月至2016年12月在梅奥诊所接受斑贴试验且在第5天和第7天或之后进行读数的患者记录。
总共有131种变应原在第5天呈阳性反应但在第7天或之后呈阴性反应，58种变应原在第5天呈阴性反应但在第7天或之后呈阳性反应。25种变应原在第5天的反应率显著高于第7天或之后。我们的标准做法是在第3天和第5天以及对于含金属的系列在第3天、第5天和第7天或之后进行读数。对于丙烯酸酯，也应考虑在第3天、第5天和第7天或之后进行读数。
