Department of Surgery, Memorial Sloan Kettering Cancer Center, New York City, New York, USA.
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York City, New York, USA
Int J Gynecol Cancer. 2020 Feb;30(2):252-260. doi: 10.1136/ijgc-2019-001032. Epub 2020 Jan 7.
Lower extremity lymphedema is a chronic, often irreversible condition that affects many patients treated for gynecologic malignancies, with published rates as high as 70% in select populations. It has consistently been shown to affect multiple quality of life metrics. This review focuses on the pathophysiology, incidence, trends, and risk factors associated with lower extremity lymphedema secondary to the treatment of cervical, endometrial, ovarian, and vulvar cancers in the era of sentinel lymph node mapping. We review traditional and contemporary approaches to diagnosis and staging, and discuss new technologies and imaging modalities. Finally, we review the data-based treatment of lower extremity lymphedema and discuss experimental treatments currently being developed. This review highlights the need for more prospective studies and objective metrics, so that we may better evaluate and serve these patients.
下肢淋巴水肿是一种慢性疾病，常不可逆转，影响许多妇科恶性肿瘤治疗后的患者，在某些特定人群中的发病率高达 70%。它一直被证明会影响多个生活质量指标。本篇综述主要聚焦于在淋巴节点绘图的时代，与宫颈癌、子宫内膜癌、卵巢癌和外阴癌的治疗相关的，继发于下肢淋巴水肿的病理生理学、发病率、趋势和风险因素。我们回顾了传统和当代的诊断和分期方法，并讨论了新技术和影像学模式。最后，我们综述了下肢淋巴水肿的基于数据的治疗方法，并讨论了目前正在开发的实验性治疗方法。这篇综述强调了需要更多的前瞻性研究和客观指标，以便我们更好地评估和治疗这些患者。
