微血管性心绞痛患者血红素氧合酶-1 基因启动子中 GT 重复多态性较长。
Subjects with microvascular angina have longer GT repeats polymorphism in the haem oxygenase-1 gene promoter.
机构信息
Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan.
Department of Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan.
出版信息
Biomarkers. 2020 Mar;25(2):144-148. doi: 10.1080/1354750X.2020.1713214. Epub 2020 Jan 20.
Few studies have investigated haem oxygenase-1 gene (HMOX1) promoter polymorphism in microvascular angina (MVA). HMOX1 promoter (GT) repeats were examined in healthy controls ( = 220) and MVA subjects ( = 181). The distribution of genotype of SS, SL and LL were significantly different in MVA (17%, 51%, 33%) vs. normal controls (35%, 46%, 20%) ( < 0.001, S allele: ≤30 repeats, L allele: >30 repeats). In multivariate analysis, carrier of L allele (odds ratio 2.772, < 0.001) was a significant predictor for the diagnosis of MVA. Subjects with MVA had longer HMOX1 promoter (GT) repeats than the healthy controls. : NCT01198730 at https://clinicaltrials.gov.
鲜有研究调查过微血管性心绞痛（MVA）中血红素加氧酶-1 基因（HMOX1）启动子多态性。在健康对照组（n=220）和 MVA 患者组（n=181）中，我们检测了 HMOX1 启动子（GT）重复序列。在 MVA 患者（SS 基因型：17%，SL 基因型：51%，LL 基因型：33%）与正常对照组（SS 基因型：35%，SL 基因型：46%，LL 基因型：20%）中，基因型的分布存在显著差异（ < 0.001，S 等位基因：≤30 个重复序列，L 等位基因：>30 个重复序列）。多变量分析显示，L 等位基因携带者（比值比 2.772， < 0.001）是 MVA 诊断的一个显著预测因子。MVA 患者的 HMOX1 启动子（GT）重复序列比健康对照组更长。NCT01198730 可在 https://clinicaltrials.gov 上查阅。
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