Department of Emergency Medicine, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina.
Department of Biostatistics, University of North Carolina-Chapel Hill, North Carolina.
J Clin Endocrinol Metab. 2020 Mar 1;105(3):e447-56. doi: 10.1210/clinem/dgaa012.
Polycystic ovary syndrome (PCOS), a condition of androgen excess in women, is associated with cardiometabolic risk factors; however, this association is not fully characterized in a population-based sample of premenopausal women and high-risk groups such as Hispanics/Latinas.
We examined the association of PCOS signs and metabolic syndrome (MetS) in premenopausal Hispanic/Latina women.
This cross-sectional analysis includes 1427 women age 24 to 44 years from the Hispanic Community Health Study/Study of Latinos. PCOS signs included menstrual cycle greater than 35 days or irregular, self-reported PCOS, and oral contraceptive use to regulate periods or acne, and a composite of 1 or more PCOS signs. We calculated odds ratios (OR) and 95% CI for MetS, accounting for sociodemographic factors and the complex survey design; an additional model included body mass index (BMI).
The mean age was 34 years and 30% reported any PCOS sign. The odds of MetS were higher in women reporting cycles greater than 35 days or irregular (OR 1.63; CI: 1.07-2.49) vs cycles 24 to 35 days, self-reported PCOS (OR 2.49; CI: 1.38-4.50) vs no PCOS, and any PCOS sign (OR 1.58; CI: 1.10-2.26) vs none. We found no association between OC use to regulate periods or acne and MetS (OR 1.1; CI: 0.6-1.8). When adjusting for BMI, only the association of self-reported PCOS and MetS was attenuated (OR 1.78; CI: 0.92-3.44).
In Hispanic/Latina women, irregular menstrual cycles, self-reported PCOS, and any PCOS sign were associated with MetS and could indicate women at metabolic disease risk.
多囊卵巢综合征（PCOS）是一种女性雄激素过多的疾病，与心血管代谢危险因素有关；然而，在基于人群的绝经前妇女和高危人群（如西班牙裔/拉丁裔）样本中，这种关联尚未完全确定。
本研究旨在探讨绝经前西班牙裔/拉丁裔妇女 PCOS 体征与代谢综合征（MetS）的关系。
本横断面分析包括来自西班牙裔社区健康研究/拉丁裔研究的 1427 名年龄在 24 至 44 岁的女性。PCOS 体征包括月经周期大于 35 天或不规则、自我报告的 PCOS、口服避孕药调节月经或痤疮，以及 1 种或多种 PCOS 体征的综合表现。我们计算了 MetS 的比值比（OR）和 95%置信区间（CI），并考虑了社会人口因素和复杂的调查设计；在另一个模型中还纳入了体重指数（BMI）。
结果显示，平均年龄为 34 岁，30%的女性报告存在任何 PCOS 体征。与月经周期为 24 至 35 天的女性相比，报告周期大于 35 天或不规则的女性发生 MetS 的几率更高（OR 1.63；95%CI：1.07-2.49），自我报告的 PCOS（OR 2.49；95%CI：1.38-4.50）与无 PCOS 的女性相比，任何 PCOS 体征（OR 1.58；95%CI：1.10-2.26）与没有 PCOS 体征的女性相比。我们没有发现调节月经或痤疮的 OC 使用与 MetS 之间存在关联（OR 1.1；95%CI：0.6-1.8）。当调整 BMI 后，只有自我报告的 PCOS 与 MetS 之间的关联减弱（OR 1.78；95%CI：0.92-3.44）。
综上所述，在西班牙裔/拉丁裔女性中，月经周期不规律、自我报告的 PCOS 以及任何 PCOS 体征均与 MetS 相关，这可能表明这些女性存在代谢疾病风险。
